中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
10期
17-20
,共4页
张靖%方怀天%周世陇%陈春兰
張靖%方懷天%週世隴%陳春蘭
장정%방부천%주세롱%진춘란
肺疾病,慢性阻塞性%噻托溴铵%沙美特罗/替卡松%运动锻炼
肺疾病,慢性阻塞性%噻託溴銨%沙美特囉/替卡鬆%運動鍛煉
폐질병,만성조새성%새탁추안%사미특라/체잡송%운동단련
Pulmonary disease,chronic obstructive%Tiotropium bromide%Salmeterol/fluticasone%Exercise
目的 观察运动锻炼配合噻托溴铵、沙美特罗/替卡松吸入对慢性阻塞性肺疾病(COPD)稳定期的疗效.方法 将COPD稳定期Ⅲ～Ⅳ级患者60例依据随机数字表法分为对照组(药物)和试验组(药物+锻炼),对照组联合吸入噻托溴铵粉雾剂及沙美特罗/替卡松干粉剂,试验组在药物治疗同时配合运动锻炼(缩唇呼吸和踏阶梯运动),疗程均为8周;治疗前后以第1秒用力呼气容积(FEV1)、FEV1占预计值百分比(FEV1%)、FEV1/用力肺活量(FVC)、MRC评分、日常生活活动能力(ADL)评分、6min步行距离(6MWD)等指标评价疗效.结果 试验组、对照组治疗前后组内各指标比较差异均有统计学意义(P<0.01);治疗后试验组、对照组FEV1[(1.41±0.25)L比(1.28±0.23)L]、FEV1%[(53.76±11.17)%比(46.27±8.85)%]、FEV1/FVC[(62.12±10.78)%比(55.76±8.57)%]、MRC评分[(1.56±1.16)分比(2.29±1.13)分]、ADL评分[(5.51±0.18)分比(4.47±0.13)分]、6MWD[(342.7±19.7)m比(280.6±17.8)m]比较差异有统计学意义(p<0.05).结论 配合运动锻炼能显著改进噻托溴铵、沙美特罗/替卡松联合吸入对COPD稳定期患者的疗效.
目的 觀察運動鍛煉配閤噻託溴銨、沙美特囉/替卡鬆吸入對慢性阻塞性肺疾病(COPD)穩定期的療效.方法 將COPD穩定期Ⅲ～Ⅳ級患者60例依據隨機數字錶法分為對照組(藥物)和試驗組(藥物+鍛煉),對照組聯閤吸入噻託溴銨粉霧劑及沙美特囉/替卡鬆榦粉劑,試驗組在藥物治療同時配閤運動鍛煉(縮脣呼吸和踏階梯運動),療程均為8週;治療前後以第1秒用力呼氣容積(FEV1)、FEV1佔預計值百分比(FEV1%)、FEV1/用力肺活量(FVC)、MRC評分、日常生活活動能力(ADL)評分、6min步行距離(6MWD)等指標評價療效.結果 試驗組、對照組治療前後組內各指標比較差異均有統計學意義(P<0.01);治療後試驗組、對照組FEV1[(1.41±0.25)L比(1.28±0.23)L]、FEV1%[(53.76±11.17)%比(46.27±8.85)%]、FEV1/FVC[(62.12±10.78)%比(55.76±8.57)%]、MRC評分[(1.56±1.16)分比(2.29±1.13)分]、ADL評分[(5.51±0.18)分比(4.47±0.13)分]、6MWD[(342.7±19.7)m比(280.6±17.8)m]比較差異有統計學意義(p<0.05).結論 配閤運動鍛煉能顯著改進噻託溴銨、沙美特囉/替卡鬆聯閤吸入對COPD穩定期患者的療效.
목적 관찰운동단련배합새탁추안、사미특라/체잡송흡입대만성조새성폐질병(COPD)은정기적료효.방법 장COPD은정기Ⅲ～Ⅳ급환자60례의거수궤수자표법분위대조조(약물)화시험조(약물+단련),대조조연합흡입새탁추안분무제급사미특라/체잡송간분제,시험조재약물치료동시배합운동단련(축진호흡화답계제운동),료정균위8주;치료전후이제1초용력호기용적(FEV1)、FEV1점예계치백분비(FEV1%)、FEV1/용력폐활량(FVC)、MRC평분、일상생활활동능력(ADL)평분、6min보행거리(6MWD)등지표평개료효.결과 시험조、대조조치료전후조내각지표비교차이균유통계학의의(P<0.01);치료후시험조、대조조FEV1[(1.41±0.25)L비(1.28±0.23)L]、FEV1%[(53.76±11.17)%비(46.27±8.85)%]、FEV1/FVC[(62.12±10.78)%비(55.76±8.57)%]、MRC평분[(1.56±1.16)분비(2.29±1.13)분]、ADL평분[(5.51±0.18)분비(4.47±0.13)분]、6MWD[(342.7±19.7)m비(280.6±17.8)m]비교차이유통계학의의(p<0.05).결론 배합운동단련능현저개진새탁추안、사미특라/체잡송연합흡입대COPD은정기환자적료효.
Objective To observe the therapeutic effects of exercise combined with tiotropium bromide and salmeterol/fluticasone inhaling on stable chronic obstructive pulmonary diseases (COPD).Methods Sixty COPD patients with pulmonary function Ⅲ-Ⅳ grade were randomly allocated into experiment group and control group (30 cases in each group).The patients in experiment group were treated with inhaled tiotropium bromide and salmeterol/fluticasone combined with excise,while the patients in control group were treated only with inhaled tiotropium bromide and salmeterol/ fluticasone.Respiratory training with shrinkage lip respiration and steps training was given to the patients in experiment group for 8 weeks.Main outcome measures included forced expiratory volume in one second (FEV1),FEV1,in the anticipation value (FEV1%),FEV1/forced vital capacity (FVC),Medical Research Council (MRC) score,activities of daily living (ADL) score and 6-minute walking distance (6MWD).Results MRC score in control group and experiment group was both lower than that of pre-treatment (P < 0.01).ADL score,6MWD and pulmonary functional parameters in both groups were improved than those of pre-treatment (P< 0.01).FEV1,FEV1%,FEV1/FVC,MRC score,ADL score and 6MWD were (1.41 ±0.25) L,(53.76 ±11.17)%,(62.12 ±10.78)%,(1.56 ± 1.16) scores,(5.51 ±0.18) scores and (342.7 ± 19.7) m after treatment in experimentgroup,and (1.28 ± 0.23) L,(46.27 ±8.85)%,(55.76 ±8.57)%,(2.29 ±1.13)scores,(4.47 ±0.13)scores and (280.6 ± 17.8)m after treatment in control group.There were significant differences between two groups (P<0.05).Conclusion Tiotropium bromide,salmeterol/ fluticasone inhaling can improve life quality and pulmonary functional parameters in patients with stable COPD,while exercise combined with that can significantly enhance the therapeutic effects.
