中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2009年
7期
679-683
,共5页
亓文婷%孙建东%徐爱强%张丽%李仁鹏%马吉祥%郭晓雷%樊庆莹%杨赫
亓文婷%孫建東%徐愛彊%張麗%李仁鵬%馬吉祥%郭曉雷%樊慶瑩%楊赫
기문정%손건동%서애강%장려%리인붕%마길상%곽효뢰%번경형%양혁
乙型肝炎病毒%疾病负担%伤残调整寿命年
乙型肝炎病毒%疾病負擔%傷殘調整壽命年
을형간염병독%질병부담%상잔조정수명년
Hepatitis B virus%Burden of disease%Disability-adjusted life years
目的 应崩伤残调整寿命年(DALYs)对山东省乙型肝炎(乙肝)、肝硬化和肝癌的疾病负担进行评价并计算HBV感染所致的总疾病负担.方法 以2004-2005年山东省第三次死因调查中乙肝、肝硬化和肝癌的死亡资料,2005年乙肝发病资料和2007年恶性肿瘤患病调查中的肝癌患病资料与残疾权重资料为基础,利用全球疾病负担研究方法分别计算三类肝病的寿命损失年(YLLs)、健康寿命损失年(YLDs)和DALYs,并估计由HBV所致的总疾病负担.结果 2005年山东省因乙肝损失211 616个DALYs(其中YLLs为39 377,YLDs为172 239),因肝硬化损失16 783个DALYs(其中YLLs为13 497,YLDs为3286),因HBV感染所致肝癌损失247 795个DALYs(其中YLLs为240 236,YLDs为7559);男性疾病负担分别是女性的2.19、2.36和3.16倍.乙肝疾病负担中以残疾所致的YLDs为主(81.39%),肝硬化和肝癌疾病负担均以早死所致的YLLs为主,分别占80.42%和96.95%.每例乙肝、肝硬化和肝癌所致的DALY损失分别为4.8、13.73和11.11.结论 乙肝、肝硬化和肝癌对山东省人群造成沉重的疾病负担;控制HBV感染具有巨大的社会和经济效益.
目的 應崩傷殘調整壽命年(DALYs)對山東省乙型肝炎(乙肝)、肝硬化和肝癌的疾病負擔進行評價併計算HBV感染所緻的總疾病負擔.方法 以2004-2005年山東省第三次死因調查中乙肝、肝硬化和肝癌的死亡資料,2005年乙肝髮病資料和2007年噁性腫瘤患病調查中的肝癌患病資料與殘疾權重資料為基礎,利用全毬疾病負擔研究方法分彆計算三類肝病的壽命損失年(YLLs)、健康壽命損失年(YLDs)和DALYs,併估計由HBV所緻的總疾病負擔.結果 2005年山東省因乙肝損失211 616箇DALYs(其中YLLs為39 377,YLDs為172 239),因肝硬化損失16 783箇DALYs(其中YLLs為13 497,YLDs為3286),因HBV感染所緻肝癌損失247 795箇DALYs(其中YLLs為240 236,YLDs為7559);男性疾病負擔分彆是女性的2.19、2.36和3.16倍.乙肝疾病負擔中以殘疾所緻的YLDs為主(81.39%),肝硬化和肝癌疾病負擔均以早死所緻的YLLs為主,分彆佔80.42%和96.95%.每例乙肝、肝硬化和肝癌所緻的DALY損失分彆為4.8、13.73和11.11.結論 乙肝、肝硬化和肝癌對山東省人群造成沉重的疾病負擔;控製HBV感染具有巨大的社會和經濟效益.
목적 응붕상잔조정수명년(DALYs)대산동성을형간염(을간)、간경화화간암적질병부담진행평개병계산HBV감염소치적총질병부담.방법 이2004-2005년산동성제삼차사인조사중을간、간경화화간암적사망자료,2005년을간발병자료화2007년악성종류환병조사중적간암환병자료여잔질권중자료위기출,이용전구질병부담연구방법분별계산삼류간병적수명손실년(YLLs)、건강수명손실년(YLDs)화DALYs,병고계유HBV소치적총질병부담.결과 2005년산동성인을간손실211 616개DALYs(기중YLLs위39 377,YLDs위172 239),인간경화손실16 783개DALYs(기중YLLs위13 497,YLDs위3286),인HBV감염소치간암손실247 795개DALYs(기중YLLs위240 236,YLDs위7559);남성질병부담분별시녀성적2.19、2.36화3.16배.을간질병부담중이잔질소치적YLDs위주(81.39%),간경화화간암질병부담균이조사소치적YLLs위주,분별점80.42%화96.95%.매례을간、간경화화간암소치적DALY손실분별위4.8、13.73화11.11.결론 을간、간경화화간암대산동성인군조성침중적질병부담;공제HBV감염구유거대적사회화경제효익.
Objective To comprehensively measure the burden of hepatitis B, liver cirrhosis and liver cancer in Shandong province, using disability-adjusted life years (DALYs) to estimate the disease burden attribute to hepatitis B virus (HBV)infection. Methods Based on the mortality data of hepatitis B, liver cirrhosis and liver cancer derived from the third National Sampling Retrospective Survey for Causes of Death during 2004 and 2005, the incidence data of hepatitis B and the prevalence and the disability weights of liver cancer gained from the Shandong Cancer Prevalence Sampling Survey in 2007, we calculated the years of life lost (YLLs), years lived with disability (YLDs) and DALYs of three diseases following the procedures developed for the global burden of disease (GBD) study to ensure the comparability. Results The total burden for hepatitis B, liver cirrhosis and liver cancer were 211 616 (39 377 YLLs and 172 239 YLDs), 16 783 (13 497 YLLs and 3286 YLDs) and 247 795 (240 236 YLLs and 7559 YLDs) DALYs in 2005 respectively, and men were 2.19, 2.36 and 3.16 times as that for women, respectively in Shandong province. The burden for hepatitis B was mainly because of disability (81.39%). However, most burden on liver cirrhosis and liver cancer were due to premature death (80.42% and 96.95%). The burden of each patient related to hepatitis B, liver cirrhosis and liver cancer were 4.8, 13.73 and 11.11 respectively. Conclusion Hepatitis B, liver cirrhosis and liver cancer caused considerable burden to the people living in Shandong province, indicating that the control of hepatitis B virus infection would bring huge potential benefits.