中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2012年
4期
295-297
,共3页
肝炎,乙型,慢性%肝炎e抗原,乙型%干扰素α%核苷类
肝炎,乙型,慢性%肝炎e抗原,乙型%榦擾素α%覈苷類
간염,을형,만성%간염e항원,을형%간우소α%핵감류
Hepatitis B,chronic%Hepatitis B e antigens%Interferon-alpha%Nueleosides
目的 探讨慢性乙型肝炎(CHB)患者抗病毒治疗过程中血清HBeAg定量动态变化对治疗应答的预测价值.方法 对接受α-干扰紊(α-IFN)治疗的53例患者和核苷类似物(NA)治疗的70例患者,采用电化学发光免疫分析法( ECLIA)测定治疗前、治疗后12、24、48周时血清HBeAg定量,并分析血清HBeAg动态定量与治疗应答相关性.结果 干扰素或核苷类似物治疗48周,完全应答者与非完全应答者血清HBeAg基线水平差异无统计学意义(P＞0.05),而治疗12、24周血清HBeAg水平及下降幅度差异有统计学意义(P＜0.05).治疗24周血清HBeAg定量水平＜100U/ml、下降幅度＞90％的患者完全应答率高(P＜0.05).结论 α-干扰素或核苷类似物治疗慢性乙型肝炎过程中,血清HBeAg定量的动态变化对治疗应答有一定的预测价值.
目的 探討慢性乙型肝炎(CHB)患者抗病毒治療過程中血清HBeAg定量動態變化對治療應答的預測價值.方法 對接受α-榦擾紊(α-IFN)治療的53例患者和覈苷類似物(NA)治療的70例患者,採用電化學髮光免疫分析法( ECLIA)測定治療前、治療後12、24、48週時血清HBeAg定量,併分析血清HBeAg動態定量與治療應答相關性.結果 榦擾素或覈苷類似物治療48週,完全應答者與非完全應答者血清HBeAg基線水平差異無統計學意義(P＞0.05),而治療12、24週血清HBeAg水平及下降幅度差異有統計學意義(P＜0.05).治療24週血清HBeAg定量水平＜100U/ml、下降幅度＞90％的患者完全應答率高(P＜0.05).結論 α-榦擾素或覈苷類似物治療慢性乙型肝炎過程中,血清HBeAg定量的動態變化對治療應答有一定的預測價值.
목적 탐토만성을형간염(CHB)환자항병독치료과정중혈청HBeAg정량동태변화대치료응답적예측개치.방법 대접수α-간우문(α-IFN)치료적53례환자화핵감유사물(NA)치료적70례환자,채용전화학발광면역분석법( ECLIA)측정치료전、치료후12、24、48주시혈청HBeAg정량,병분석혈청HBeAg동태정량여치료응답상관성.결과 간우소혹핵감유사물치료48주,완전응답자여비완전응답자혈청HBeAg기선수평차이무통계학의의(P＞0.05),이치료12、24주혈청HBeAg수평급하강폭도차이유통계학의의(P＜0.05).치료24주혈청HBeAg정량수평＜100U/ml、하강폭도＞90％적환자완전응답솔고(P＜0.05).결론 α-간우소혹핵감유사물치료만성을형간염과정중,혈청HBeAg정량적동태변화대치료응답유일정적예측개치.
Objective To observe the changes in quantity of serum HBeAg and the Correlation with response during chronic hepatitis B treatment using interferon-alpha or nucleotside analogue,evaluate the predictive value of dynamic HBeAg quantitation to antiviral response.Methods 53 cases treated with interferon-alpha and 70 cases treated with nucleotide analogue for 48 weeks.Used the Electro chemiluminescence immunoassay(ECLIA) to measure the quantity of the serum HBeAg before treatment and 12 weeks,24 weeks and 48 weeks after treatment,analysis the correlation of dynamic HBeAg quantitation with antiviral response.Results After 48 weeks treatment,whether interferon-alpha group or nucleotide analogue group,the complete responser quantity of HBeAg before treatment was no significant correlation compared with non-complete responser( P ＞ 0.05 ),but at treatment weeks 12 and 24 had correlation with the serum HBeAg level and HBeAg decline degree (P ＜ 0.05 ),deferent HBeAg titer and HBeAg quantatition decline degree during treatment achieved deferent complete response rate,HBeAg titer lesser than 100 U/ml and HBeAg quantatition decline degree higher than 90％ at treatment weeks 24 achieved more complete response rate After 48 weeks treatment.Conclusion During the treatment CHB with interferon-alpha or nucleotside analogue,the dynamic changes in quantity of serum HBeAg has a relationship with response.
