中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2004年
21期
4368-4371
,共4页
李河%麦劲壮%饶栩栩%李义和%石美玲%刘小清%邓木兰%吴勇%高向民
李河%麥勁壯%饒栩栩%李義和%石美玲%劉小清%鄧木蘭%吳勇%高嚮民
리하%맥경장%요허허%리의화%석미령%류소청%산목란%오용%고향민
冠状动脉疾病%胆固醇/血液%甘油三酯类/血液%人体测量术%体重%臀%回归分析
冠狀動脈疾病%膽固醇/血液%甘油三酯類/血液%人體測量術%體重%臀%迴歸分析
관상동맥질병%담고순/혈액%감유삼지류/혈액%인체측량술%체중%둔%회귀분석
背景:由于危险因素致动脉粥样硬化(atherosclerosis disease,AS)/冠心病存在协同/交互作用,危险因素常趋向交集(聚集性)及表现以某种组合而导致AS/冠心病,如体质量指数(body mass index,BMI)及腰臀比的增加与某些危险因素水平的增高相关,但这些结果主要来源于高AS/冠心病患病率的西方人群.目的:探讨在低AS、低冠心病患病率女性人群中BMI、腰臀比的线性组合与总胆固醇、三酰甘油、高密度脂蛋白胆固醇(high densitylipoprotein cholesterol,HDL-C)的线性组合是否存在更高的相关性及相关特征,以便进一步认识AS/冠心病的危险因素.同时初步探讨血脂指标预测BMI、腰臀比的重要性.设计:横断面调查研究.地点、对象和方法:采用现况研究方法,于1995年对广东省479例女性对象进行调查,所有步骤遵循中澳合作项目研究方案.主要观察指标:479例女性研究对象身高、体质量、腰围、臀围及血脂指标总胆固醇、三酰甘油、HDL-C分析结果.结果:①BMI、腰臀比、总胆固醇、三酰甘油、HDL-C分别为(21.61±3.39)kg/m2,0.80±0.06,(4.24±0.79),(1.13±0.57),(1.31±0.32)mmol/L.②BMI与总胆固醇、三酰甘油呈正相关(r=0.11265,P＜0.05;r=0.30519,P＜0.01).BMI与HDL-C呈负相关(r=-0.15809,P＜0.01).腰臀比与总胆固醇、三酰甘油呈正相关(r=0.16969,0.40034,P＜0.01).腰臀比与HDL-C呈负相关(r=-0.12936,P＜0.01).③身体测量与血脂两组指标间典型相关系数R1,can=0.451 050(F=19.49,P＜0.0001;V1=0.2877×BMI'+0.7914×腰臀比',W1=0.1840×总胆固醇'+0.8818×三酰甘油'-0.4300×HDL-C').④标准逐步回归方程分别为腰臀比=0.414 37×三酰甘油'-0.164 68×HDL-C'(P＜0.0001);BMI=0.321 00×三酰甘油'-0.185 45×HDL-C'(P＜0.0001).结论:腰臀比可作为一标志反映高危险个体(或人群),及危险因素线性组合可作为AS/冠心病的(预测)测量指标;在低AS、低冠心病患病率女性人群中,高BMI、腰臀比与血脂指标总胆固醇、三酰甘油、HDL-C及两指标组间存在相关性,因此对该危险因素进行预防/干预,特别是针对可控制的危险因素是非常重要的,甚至可在青壮年时期或更早期就对该危险因素进行预防/干预.
揹景:由于危險因素緻動脈粥樣硬化(atherosclerosis disease,AS)/冠心病存在協同/交互作用,危險因素常趨嚮交集(聚集性)及錶現以某種組閤而導緻AS/冠心病,如體質量指數(body mass index,BMI)及腰臀比的增加與某些危險因素水平的增高相關,但這些結果主要來源于高AS/冠心病患病率的西方人群.目的:探討在低AS、低冠心病患病率女性人群中BMI、腰臀比的線性組閤與總膽固醇、三酰甘油、高密度脂蛋白膽固醇(high densitylipoprotein cholesterol,HDL-C)的線性組閤是否存在更高的相關性及相關特徵,以便進一步認識AS/冠心病的危險因素.同時初步探討血脂指標預測BMI、腰臀比的重要性.設計:橫斷麵調查研究.地點、對象和方法:採用現況研究方法,于1995年對廣東省479例女性對象進行調查,所有步驟遵循中澳閤作項目研究方案.主要觀察指標:479例女性研究對象身高、體質量、腰圍、臀圍及血脂指標總膽固醇、三酰甘油、HDL-C分析結果.結果:①BMI、腰臀比、總膽固醇、三酰甘油、HDL-C分彆為(21.61±3.39)kg/m2,0.80±0.06,(4.24±0.79),(1.13±0.57),(1.31±0.32)mmol/L.②BMI與總膽固醇、三酰甘油呈正相關(r=0.11265,P＜0.05;r=0.30519,P＜0.01).BMI與HDL-C呈負相關(r=-0.15809,P＜0.01).腰臀比與總膽固醇、三酰甘油呈正相關(r=0.16969,0.40034,P＜0.01).腰臀比與HDL-C呈負相關(r=-0.12936,P＜0.01).③身體測量與血脂兩組指標間典型相關繫數R1,can=0.451 050(F=19.49,P＜0.0001;V1=0.2877×BMI'+0.7914×腰臀比',W1=0.1840×總膽固醇'+0.8818×三酰甘油'-0.4300×HDL-C').④標準逐步迴歸方程分彆為腰臀比=0.414 37×三酰甘油'-0.164 68×HDL-C'(P＜0.0001);BMI=0.321 00×三酰甘油'-0.185 45×HDL-C'(P＜0.0001).結論:腰臀比可作為一標誌反映高危險箇體(或人群),及危險因素線性組閤可作為AS/冠心病的(預測)測量指標;在低AS、低冠心病患病率女性人群中,高BMI、腰臀比與血脂指標總膽固醇、三酰甘油、HDL-C及兩指標組間存在相關性,因此對該危險因素進行預防/榦預,特彆是針對可控製的危險因素是非常重要的,甚至可在青壯年時期或更早期就對該危險因素進行預防/榦預.
배경:유우위험인소치동맥죽양경화(atherosclerosis disease,AS)/관심병존재협동/교호작용,위험인소상추향교집(취집성)급표현이모충조합이도치AS/관심병,여체질량지수(body mass index,BMI)급요둔비적증가여모사위험인소수평적증고상관,단저사결과주요래원우고AS/관심병환병솔적서방인군.목적:탐토재저AS、저관심병환병솔녀성인군중BMI、요둔비적선성조합여총담고순、삼선감유、고밀도지단백담고순(high densitylipoprotein cholesterol,HDL-C)적선성조합시부존재경고적상관성급상관특정,이편진일보인식AS/관심병적위험인소.동시초보탐토혈지지표예측BMI、요둔비적중요성.설계:횡단면조사연구.지점、대상화방법:채용현황연구방법,우1995년대광동성479례녀성대상진행조사,소유보취준순중오합작항목연구방안.주요관찰지표:479례녀성연구대상신고、체질량、요위、둔위급혈지지표총담고순、삼선감유、HDL-C분석결과.결과:①BMI、요둔비、총담고순、삼선감유、HDL-C분별위(21.61±3.39)kg/m2,0.80±0.06,(4.24±0.79),(1.13±0.57),(1.31±0.32)mmol/L.②BMI여총담고순、삼선감유정정상관(r=0.11265,P＜0.05;r=0.30519,P＜0.01).BMI여HDL-C정부상관(r=-0.15809,P＜0.01).요둔비여총담고순、삼선감유정정상관(r=0.16969,0.40034,P＜0.01).요둔비여HDL-C정부상관(r=-0.12936,P＜0.01).③신체측량여혈지량조지표간전형상관계수R1,can=0.451 050(F=19.49,P＜0.0001;V1=0.2877×BMI'+0.7914×요둔비',W1=0.1840×총담고순'+0.8818×삼선감유'-0.4300×HDL-C').④표준축보회귀방정분별위요둔비=0.414 37×삼선감유'-0.164 68×HDL-C'(P＜0.0001);BMI=0.321 00×삼선감유'-0.185 45×HDL-C'(P＜0.0001).결론:요둔비가작위일표지반영고위험개체(혹인군),급위험인소선성조합가작위AS/관심병적(예측)측량지표;재저AS、저관심병환병솔녀성인군중,고BMI、요둔비여혈지지표총담고순、삼선감유、HDL-C급량지표조간존재상관성,인차대해위험인소진행예방/간예,특별시침대가공제적위험인소시비상중요적,심지가재청장년시기혹경조기취대해위험인소진행예방/간예.
BACKGROUND:Since the risk factors tend to reinforce/interact with each other in their influence on atherosclerosis (AS) /coronary heart disease (CHD), risk factors tend to aggregate and usually appear in some combinations to cause the diseases.For example, the elevation of body mass index (BMI) and waistline hipline ratio (WHR) are associated with elevated levels of several vardiovascular risk facotrs, but which was based primarily on data from Western populations living with high prevalence of AS/CHD.OBJECTIVE:To explore whether a linear combination of BMI and WHR had stronger association with a linear combination of recognized risk factor serum lipids total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) in the females with low prevalence of ASD/CHD, so to further recognize the risk factors to AS/CHD.We also hoped to determine the relative importance of serum lipids predicting BMI and WHR.DESIGN:Cross sectional study.SETTING, PARTICIP NTS and INTERVENTIONS:With cross sectional study, 479 females were surveyed in 1995 in Guangdong Province,China.All the procedures followed the standards from the China-Australia collaboration program.The main study variables:body measurements height,weight, waistline, hipline of 479 female paricipants; and the serum lipids TC,TG and HDL-C were analyzed.3.39) kg/m2, (0.80±0.06), (4.24±0.79), (1.13±0.57), (1.31±TG(r=0.11265, P ＜0.05; r=0.30519, P ＜0.01).BMI was negatively correlated with HDL-C( r = -0.15809, P ＜ 0.01).WHR was significantly correlated with TC and TG (r =0.16969, 0.40034, P ＜ 0.01) .WHR was canonical correlation coefficient between the body measurements and serum lipids was R1 Can =0.451 050( F = 19.49, P ＜ 0.000 1) between V1 and W1(V1=0.2877×BMI' +0.7914×WHR' andW1= 0.1840×TC' +0.881quation were:WHR =0.414 37 ×TG' -0.164 68 × HDL-C' ( P ＜0.0001);BMI =0.321 00 ×TG' -0.185 45 × HDL-C' (P ＜0.000 1).CONCLUSION:It appeared that WHR could be a marker to identify individuals (or population) at high risk, and the linear combination of the risk factors could behave as a measure of ASD/CHD.These data confirmed that correlation existed between BMI, WHR and blood lipids TC, TG, HDL-C and between body measurement and blood lipids, even in population with low prevalence of ASD/CHD, such as females from Guangdong Province in China.So, it is important to prevent/intervene in these risk factors, especially the modifiable risk factors, even in youths or earlier.
