CAJ | 학술논문

目的探讨TGF-β1、wt-p53基因在前列腺癌组织中的表达并探讨其临床意义.方法应用免疫印迹技术检测正常前列腺、前列腺癌组织和癌旁组织中TGF-β1,wt-p53基因的表达.结果正常前列腺外腺和癌旁组织间的TGF-β1、wt-p53表达水平无差异(P>0.05);前列腺癌组织中TGF-β1和wt-p53表达,与正常前列腺组织和癌旁组织相比差异显著(P<0.01);已有远处转移灶的前列腺癌组织中TGF-β1和wt-p53表达,与无转移灶者相比差异显著(P<0.01).结论 TGF-β1和wt-p53基因与前列腺癌的发生和转移相关,并可能在前列腺癌的进展中起重要作用.因此,借助测定TGF-β1与wt-p53表达可辅助前列腺癌的诊断和评估预后.
목적 탐토TGF-β1、wt-p53기인재전렬선암조직중적표체병탐토기림상의의.방법 응용면역인적기술검측정상전렬선、전렬선암조직화암방조직중TGF-β1,wt-p53기인적표체.결과 정상전렬선외선화암방조직간적TGF-β1、wt-p53표체수평무차이(P>0.05);전렬선암조직중TGF-β1화wt-p53표체,여정상전렬선조직화암방조직상비차이현저(P<0.01);이유원처전이조적전렬선암조직중TGF-β1화wt-p53표체,여무전이조자상비차이현저(P<0.01).결론 TGF-β1화wt-p53기인여전렬선암적발생화전이상관,병가능재전렬선암적진전중기중요작용.인차,차조측정TGF-β1여wt-p53표체가보조전렬선암적진단화평고예후.
Objective To detect the expressions of TGF-β1 and wt-p53 gene in prostate carcinoma and evaluate its significances.Methods Western blotting method was used to detect TGF-β1 and wt-p53 expression in the normal and carcinomous prostatic tissues.Results TGF-β1 was similarly expressed in the normal and prostatic paraneoplastic tissues(P>0.05),and so was wt-p53(P>0.05). Either TGF-β1 or wt-p53 was differently expressed in the carcinomous prostatic tissues compared with normal or paraneoplastic tissues(P<0.01).The expressions of TGF-β1 or wt-p53 were statistically different between metastatic prostate carcinoma and non-metastatic carcinoma(P<0.01).Concmusions TGF-β1 and wt-p53 genes are related to the malignant transformation and metastatis of prostate carcinoma.To detect the expressions of TGF-β1 and wt-p53 may make for judging prostate cancer's diagnosis and prognosis.