光谱学与光谱分析
光譜學與光譜分析
광보학여광보분석
SPECTROSCOPY AND SPECTRAL ANALYSIS
2010年
5期
1386-1390
,共5页
周花蕾%董逸帆%杨运旭%邓小容%鲁毅强
週花蕾%董逸帆%楊運旭%鄧小容%魯毅彊
주화뢰%동일범%양운욱%산소용%로의강
Salen%Mn(Ⅱ)%Salen%Eu(Ⅲ)%O2·-%DNA%光谱
Salen%Mn(Ⅱ)%Salen%Eu(Ⅲ)%O2·-%DNA%光譜
Salen%Mn(Ⅱ)%Salen%Eu(Ⅲ)%O2·-%DNA%광보
Salen Mn(Ⅱ)%Salen Eu(Ⅲ)%O2·-%DNA%Spectra
合成了5种Salen Mn(Ⅱ)及2种Salen Eu(Ⅲ)配合物.以NBT/核黄素(VB2)/蛋氨酸为O2·-的产生、检测体系,对上述配合物进行了抗O2·-活性研究,发现Mn(Ⅱ)配合物对O2·-均具有较为明显的清除活性.用荧光检测法对上述配合物与ct-DNA的作用进行了研究,结果显示其均能与DNA产生结合作用,提示具有潜在抗癌活性.
閤成瞭5種Salen Mn(Ⅱ)及2種Salen Eu(Ⅲ)配閤物.以NBT/覈黃素(VB2)/蛋氨痠為O2·-的產生、檢測體繫,對上述配閤物進行瞭抗O2·-活性研究,髮現Mn(Ⅱ)配閤物對O2·-均具有較為明顯的清除活性.用熒光檢測法對上述配閤物與ct-DNA的作用進行瞭研究,結果顯示其均能與DNA產生結閤作用,提示具有潛在抗癌活性.
합성료5충Salen Mn(Ⅱ)급2충Salen Eu(Ⅲ)배합물.이NBT/핵황소(VB2)/단안산위O2·-적산생、검측체계,대상술배합물진행료항O2·-활성연구,발현Mn(Ⅱ)배합물대O2·-균구유교위명현적청제활성.용형광검측법대상술배합물여ct-DNA적작용진행료연구,결과현시기균능여DNA산생결합작용,제시구유잠재항암활성.
Five kinds of Salen Mn(Ⅱ) and two kinds of Eu(Ⅲ) complexes were synthesized.Under the system of NBT/L-methionine, which creats and detects O·2-,the complexes of antioxidant activity were studied, and the conclusion revealed that all Mn(Ⅱ) complexes have obvious antioxidant activity.The fluorescence study indicated that all the Salen metal complexes could bind with DNA,which shows their potential anticancer activity.
