CAJ | 학술논문

目的研究直肠癌中基质金属蛋白酶2(MMP2)及其组织抑制物2(TIMP2)的表达与直肠癌细胞分级、临床病理分期的关系及其在评估患者预后中的意义.方法免疫组化法检测直肠癌原发灶MMP2、TIMP2表达水平,χ2检验进行统计学分析,应用Kaplan-Meier法进行单因素生存分析(Log-rank检验).结果直肠癌组织中MMP2及TIMP2表达显著高于正常直肠组织.随恶性程度升高,MMP2表达呈增加趋势,而TIMP2表达呈下降趋势.直肠癌中MMP2与TIMP2呈负相关.结论直肠癌组织中MMP2与TIMP2的表达与直肠癌的细胞分级、临床病理分期和预后有关,MMP2表达水平及MMP2与TIMP2的失衡在直肠癌的侵袭发挥重要作用.MMV2表达水平及MMP2与TIMP2的平衡状况可作为评估直肠癌预后的指标,并能为探寻新的治疗方法提供线索和依据.
목적 연구직장암중기질금속단백매2(MMP2)급기조직억제물2(TIMP2)적표체여직장암세포분급、림상병리분기적관계급기재평고환자예후중적의의.방법 면역조화법검측직장암원발조MMP2、TIMP2표체수평,χ2검험진행통계학분석,응용Kaplan-Meier법진행단인소생존분석(Log-rank검험).결과 직장암조직중MMP2급TIMP2표체현저고우정상직장조직.수악성정도승고,MMP2표체정증가추세,이TIMP2표체정하강추세.직장암중MMP2여TIMP2정부상관.결론 직장암조직중MMP2여TIMP2적표체여직장암적세포분급、림상병리분기화예후유관,MMP2표체수평급MMP2여TIMP2적실형재직장암적침습발휘중요작용.MMV2표체수평급MMP2여TIMP2적평형상황가작위평고직장암예후적지표,병능위탐심신적치료방법 제공선색화의거.
Objective Studing the relationship among matrixmetal-loproteinnse2 (MMP2), the tissue inhibitors of metalloprotein-ase2 (TIMP2) and chnicopathological characteristics such as histological grade, clinicopathological stage of the rectal cancer. Assessing the significance of MMP2 and TIMP2 expression in rec-tal cancer for prognosis and treatment. Methods To test the expression level of MMP2 and TIMP2 in rectal caneer patients with immunohistochemisty method. Results were analysised with χ2 test. The Kaplan-Meier (Log-rank test) was used for univariate survival analysis. Results The positive rates of MMP2 and T1MP2 ex-pression in rectal cance are higher in comparison with normal tissues. With MMP2 have a trendence of increas-ing the positive expression of TIMP2 decreases. Conclusion MMP2 and TIMP2 relate obviously with the clini-copathological character of the rectal cancer. They may play an important role in the proliferation, invasion and of the cancer. Testing the level of expression of MMP2 and TIMP2 may be helpful to prejudge the prognosis of the patients with rectal cancer. Some new therapic methods relating to MMP2 and TIMP2 may give patients with rectal cancer a more satisfying treatment.