CAJ | 학술논문

mRNA的选择性剪接可以使基因产生新的结构与功能,是基因表达调控的重要机制.神经系统中大部分的差异剪接基因与信号传导和调节有关,包括转录因子、受体、离子通道等,这些差异剪接影响细胞内基因的转录调控、信号传导、离子通道的动力学,从而对神经系统的发育、功能以及内环境的稳定性具有重要的调节作用.差异剪接的异常导致神经系统的疾病和肿瘤,因此可以作为治疗的靶标.
mRNA적선택성전접가이사기인산생신적결구여공능,시기인표체조공적중요궤제.신경계통중대부분적차이전접기인여신호전도화조절유관,포괄전록인자、수체、리자통도등,저사차이전접영향세포내기인적전록조공、신호전도、리자통도적동역학,종이대신경계통적발육、공능이급내배경적은정성구유중요적조절작용.차이전접적이상도치신경계통적질병화종류,인차가이작위치료적파표.
mRNA alternative splicing is widely recognized to be a ubiquitous mechanism for controlling gene expression, through which genes can generate structural and functional diversities. The majority of alternative spliced genes in the nervous system were found to transmit and regulate signals, which include transcription factors, receptors and ion channels. Alternative splicing plays a pivotal role in development, function and ho-meostasis of the nervous system by affecting transcriptional regulation, signal transduction and ion channel dynamics. Errors in alternative splicing can cause neural disorders and cancers, and thus can be used as therapeutic targets.