中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
14期
967-969
,共3页
林少达%陈仲贤%林楚佳%段红艳
林少達%陳仲賢%林楚佳%段紅豔
림소체%진중현%림초가%단홍염
胰高血糖素%糖尿病,2型%C肽%生长激素释放肽
胰高血糖素%糖尿病,2型%C肽%生長激素釋放肽
이고혈당소%당뇨병,2형%C태%생장격소석방태
Glucngon%Diabetes mellitus,type 2%C-peptide%Ghrelin
目的 探讨外源性胰高血糖素对2型糖尿病(T2DM)病人生长激素释放肽(ghrelin)分泌的影响.方法 研究对象为2006年5月至2007年12月汕头大学医学院第一附属医院门诊和住院治疗T2DM病人38例(T2DM组),正常健康人(NC组)30名行胰高血糖素-C肽释放试验,同步取血测定血浆ghrelin、C肽.结果 (1)两组空腹C肽差异无统计学意义;静脉注射胰高血糖素6 min后:两组C肽均比空腹明显升高,差异有统计学意义[T2DM组:(2.0±0.8)μg/L比(1.3±0.6)μg/L,NC组:(3.0±0.8)μg/L比(1.2±0.4)μg/L,均P<0.01],但T2DM组仍低于NC组;两组ghretin均有下降,NC组ghretin比空腹下降显著(2.3±0.7)μg/L比(2.7±0.8)μg/L,P<0.01),T2DM组ghrelin无明显下降[(2.9±0.9)μg/L比(3.0±1.0)μg/L],差异无统计学意义(P>0.05);(2)空腹血浆ghrelin水平与腰围呈负相关(r=0.343,P<0.01),是它的独立预测因子.结论 ghrelin分泌可能与T2DM病人胰岛β细胞功能减退及早相胰岛素分泌缺陷有关;胰岛素、胰高血糖素及ghrelin可能相瓦作用影响糖调节.
目的 探討外源性胰高血糖素對2型糖尿病(T2DM)病人生長激素釋放肽(ghrelin)分泌的影響.方法 研究對象為2006年5月至2007年12月汕頭大學醫學院第一附屬醫院門診和住院治療T2DM病人38例(T2DM組),正常健康人(NC組)30名行胰高血糖素-C肽釋放試驗,同步取血測定血漿ghrelin、C肽.結果 (1)兩組空腹C肽差異無統計學意義;靜脈註射胰高血糖素6 min後:兩組C肽均比空腹明顯升高,差異有統計學意義[T2DM組:(2.0±0.8)μg/L比(1.3±0.6)μg/L,NC組:(3.0±0.8)μg/L比(1.2±0.4)μg/L,均P<0.01],但T2DM組仍低于NC組;兩組ghretin均有下降,NC組ghretin比空腹下降顯著(2.3±0.7)μg/L比(2.7±0.8)μg/L,P<0.01),T2DM組ghrelin無明顯下降[(2.9±0.9)μg/L比(3.0±1.0)μg/L],差異無統計學意義(P>0.05);(2)空腹血漿ghrelin水平與腰圍呈負相關(r=0.343,P<0.01),是它的獨立預測因子.結論 ghrelin分泌可能與T2DM病人胰島β細胞功能減退及早相胰島素分泌缺陷有關;胰島素、胰高血糖素及ghrelin可能相瓦作用影響糖調節.
목적 탐토외원성이고혈당소대2형당뇨병(T2DM)병인생장격소석방태(ghrelin)분비적영향.방법 연구대상위2006년5월지2007년12월산두대학의학원제일부속의원문진화주원치료T2DM병인38례(T2DM조),정상건강인(NC조)30명행이고혈당소-C태석방시험,동보취혈측정혈장ghrelin、C태.결과 (1)량조공복C태차이무통계학의의;정맥주사이고혈당소6 min후:량조C태균비공복명현승고,차이유통계학의의[T2DM조:(2.0±0.8)μg/L비(1.3±0.6)μg/L,NC조:(3.0±0.8)μg/L비(1.2±0.4)μg/L,균P<0.01],단T2DM조잉저우NC조;량조ghretin균유하강,NC조ghretin비공복하강현저(2.3±0.7)μg/L비(2.7±0.8)μg/L,P<0.01),T2DM조ghrelin무명현하강[(2.9±0.9)μg/L비(3.0±1.0)μg/L],차이무통계학의의(P>0.05);(2)공복혈장ghrelin수평여요위정부상관(r=0.343,P<0.01),시타적독립예측인자.결론 ghrelin분비가능여T2DM병인이도β세포공능감퇴급조상이도소분비결함유관;이도소、이고혈당소급ghrelin가능상와작용영향당조절.
Objective To investigate the effect of glucagon on ghrelin seretion in type 2 diabetes mellitus(T2DM)patients.Methods Circulating ghrelin and C-pepetide were measured during glucagon stimulation test in 38 cases with T2DM and 30 cases in normal controls(NC)at the 1st Affiliated Hospital of Shantou University from May 2006 to December 2007.Results(1)There w88 no significant difference in the fasting C-peptide and fasting ghrelin levels of the NC group were(1.3±0.6)μg/L and(3.0±1.0)ng/ml respectively,both not significantly different from those of the T2DM group[(1.2±0.4)μg/L and (2.7±0.8)μg/L respectively,P>0.05 and P>0.05];six minutes after the injection of glucagon,the C-peptide level of the T2DM group increased to(2.0±0.8)μg/L(P<0.01),and that of the NC group increased to(3.0±0.8)μg/L(P<0.01),and the C-peptide level 6 min after of the T2DM group was significantly lower than that of the NC group(P<0.01).The ghrelin level 6 min after the injection of glucagon of the NC group wss(2.3±0.7)μg/L,significantly lower than that before the injection(P<0.01).But the ghrelin level 6 min after the injection of glucagon of the T2DM group was(2.9±0.9)μg/L,NOT significantly different from that before the injection(P>0.05).(2)Fasting ghrelin level was significantly negatively correlated with the waist circumference(r=0.343,P<0.05).Conclusion In healthy subjects exogenous slucagon decreases the ghrelin level.Ghrelin may be associated with the beta-cell hypofunetion and first-phase insulin socretion defects in T2DM.Insulin,glucagon,and ghretin secreted influence each other to regulate glucose homeostasis.
