中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
16期
12-14
,共3页
内脂素%突发性耳聋%中性粒细胞激活肽-78
內脂素%突髮性耳聾%中性粒細胞激活肽-78
내지소%돌발성이롱%중성립세포격활태-78
Visfatin%Idiopathic sudden sensorineural hearing loss%Epithelial neutrophil-activing peptide-78 ( ENA-78 )
目的 探讨突发性耳聋患者血清内脂素(visfatin)和中性粒细胞激活肽-78( ENA-78)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 采用酶联免疫吸附试验检测血清内脂素和ENA-78含量；检测102例突发性耳聋患者,35例其他疾病对照组和30例正常健康对照组的血清内脂素和ENA-78含量,比较治疗前后血清内脂素和ENA-78的测定结果.结果 突发性耳聋患者治疗前血清内脂素和ENA-78含量较两对照组显著升高(P＜0.01)；治疗后恢复组患者内脂素和ENA-78含量明显降低.同时突发性耳聋重度组患者血清内脂素和ENA-78浓度明显高于中、轻度组,中度组患者明显高于轻度组,且差异有统计学意义(P＜0.01).突发性耳聋患者血清内脂素和ENA-78含量之间呈正相关(r=0.68,P＜0.01).结论 血清内脂素和ENA-78水平的变化与突发性耳聋病情严重程度密切相关.
目的 探討突髮性耳聾患者血清內脂素(visfatin)和中性粒細胞激活肽-78( ENA-78)的含量變化,及其在突髮性耳聾髮生過程中的作用和意義.方法 採用酶聯免疫吸附試驗檢測血清內脂素和ENA-78含量；檢測102例突髮性耳聾患者,35例其他疾病對照組和30例正常健康對照組的血清內脂素和ENA-78含量,比較治療前後血清內脂素和ENA-78的測定結果.結果 突髮性耳聾患者治療前血清內脂素和ENA-78含量較兩對照組顯著升高(P＜0.01)；治療後恢複組患者內脂素和ENA-78含量明顯降低.同時突髮性耳聾重度組患者血清內脂素和ENA-78濃度明顯高于中、輕度組,中度組患者明顯高于輕度組,且差異有統計學意義(P＜0.01).突髮性耳聾患者血清內脂素和ENA-78含量之間呈正相關(r=0.68,P＜0.01).結論 血清內脂素和ENA-78水平的變化與突髮性耳聾病情嚴重程度密切相關.
목적 탐토돌발성이롱환자혈청내지소(visfatin)화중성립세포격활태-78( ENA-78)적함량변화,급기재돌발성이롱발생과정중적작용화의의.방법 채용매련면역흡부시험검측혈청내지소화ENA-78함량；검측102례돌발성이롱환자,35례기타질병대조조화30례정상건강대조조적혈청내지소화ENA-78함량,비교치료전후혈청내지소화ENA-78적측정결과.결과 돌발성이롱환자치료전혈청내지소화ENA-78함량교량대조조현저승고(P＜0.01)；치료후회복조환자내지소화ENA-78함량명현강저.동시돌발성이롱중도조환자혈청내지소화ENA-78농도명현고우중、경도조,중도조환자명현고우경도조,차차이유통계학의의(P＜0.01).돌발성이롱환자혈청내지소화ENA-78함량지간정정상관(r=0.68,P＜0.01).결론 혈청내지소화ENA-78수평적변화여돌발성이롱병정엄중정도밀절상관.
Objective To study the role and clinical significance of serum visfatin and epithelial neutrophil-activing peptide-78 ( ENA-78 ) in idiopathic sudden sensorineural hearing loss by measuring the changes in the patients with idiopathic sudden sensorineural hearing loss.Methods The levels of visfatin and ENA-78 were determined by ELISA method in 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points:before and after treatment,and thirty-five patients with other neurologic diseases (20 with sciatica,16 with trigeminal neuralgia) and thirty healthy people were enrolled in control group.Results The levels of serum visfatin and ENA-78 in patients with idiopathic sudden sensorineural hearing loss were markedly higher than those of the other two control groups (P ＜ 0.01 ) ; The levels of serum visfatin and ENA-78 in the idiopathic sudden sensorineural hearing loss group after treatment were significantly lower than those before treatment ( P ＜ 0.01 ).The levels of serum visfatin and ENA-78 in the severe group were higher than those in the morderate and mild group,and also were higher in the morderate group than those in the mild group ( P ＜0.01 ).There was a correlation between visfatin and ENA-78 expression in patients with idiopathic sudden sensorineural hearing loss ( r =0.68,P ＜ 0.01 ).Conclusions The levels of serum visfatin and ENA-78 are correlated with the degree of idiopathic sudden sensorineural hearing loss.
