CAJ | 학술논문

目的分析供、受者年龄,受者性别,术前原发疾病,肝、肾功能以及免疫抑制剂的使用对移植肝的急性排斥反应产生的影响.方法对玛丽医院从1991年10月至1998年9月发生移植肝急性排斥反应的所有病例进行回顾性分析.结果 81例患者做了83例次肝移植,共发生急性排斥反应70例次,发生率为53%.经过统计学分析,发现使用普乐可复(FK506)的受者,急性排斥反应的发生率较使用环孢素A和硫唑嘌呤组为低.供、受者的年龄,受者性别,术前原发疾病以及肝、肾功能对急性排斥的发生没有明显的影响.结论 FK506不仅能够明显降低急性排斥反应的发生率,而且能够有效治疗该并发症.
목적 분석공、수자년령,수자성별,술전원발질병,간、신공능이급면역억제제적사용대이식간적급성배척반응산생적영향.방법 대마려의원종1991년10월지1998년9월발생이식간급성배척반응적소유병례진행회고성분석.결과 81례환자주료83례차간이식,공발생급성배척반응70례차,발생솔위53%.경과통계학분석,발현사용보악가복(FK506)적수자,급성배척반응적발생솔교사용배포소A화류서표령조위저.공、수자적년령,수자성별,술전원발질병이급간、신공능대급성배척적발생몰유명현적영향.결론 FK506불부능구명현강저급성배척반응적발생솔,이차능구유효치료해병발증.
Objective To investigate whether the incidence of acute rejection was influenced by the age of donors and recipients,recipients'sex,primary diseases,pre-operative liver biochemistry and renal function,and the use of immunosuppressive drugs.Methods Eighty-three transplants at Queen Mary Hospital from October 1991 to September 1998 were analyzed retrospectively.Results The age of the donors and recipients,recipients'sex,primary diseases,and pre-operative liver biochemistry and renal function did not significantly influence the incidence of acute rejection(P>0.05).The incidence of rejection in the group of patients who received FK506 treatment was lower than that in cyclosporine A and azathioprinetreated group.Conclusion The use of immunosuppressive drugs may influence the episode of acute rejection.Incidence of acute rejection can be decreased by using FK506.