CAJ | 학술논문

目的分析114例特发性夜间额叶癫痫(NFLE)患者的临床特征、脑电图和神经影像学表现、治疗效果及预后.方法回顾性分析解放军总医院癫痫门诊自1999年6月至2007年1月收治的114例NFLE患者的临床资料.结果 NFLE以夜间成串的偏转性、姿势性强直及过度运动发作为最显著的临床特征;本组22.9%清醒发作间期常规脑电图及28%清醒发作间期动态脑电图可见额叶癫痫样放电,38%睡眠发作间期动态脑电图可见额叶癫痫样放电,66.7%发作期脑电图可见额叶癫痫样放电;79.8%药物治疗有效,其中29.7%可完全控制.结论 NTLE具有特征性的临床发作特点,发作期及发作间期脑电图改变阳性率不高,临床上应注意鉴别.额叶癫痫容易在夜间发作,睡眠腩电图对NFLE具有重要的诊断价值.
목적 분석114례특발성야간액협전간(NFLE)환자적림상특정、뇌전도화신경영상학표현、치료효과급예후.방법 회고성분석해방군총의원전간문진자1999년6월지2007년1월수치적114례NFLE환자적림상자료.결과 NFLE이야간성천적편전성、자세성강직급과도운동발작위최현저적림상특정;본조22.9%청성발작간기상규뇌전도급28%청성발작간기동태뇌전도가견액협전간양방전,38%수면발작간기동태뇌전도가견액협전간양방전,66.7%발작기뇌전도가견액협전간양방전;79.8%약물치료유효,기중29.7%가완전공제.결론 NTLE구유특정성적림상발작특점,발작기급발작간기뇌전도개변양성솔불고,림상상응주의감별.액협전간용역재야간발작,수면남전도대NFLE구유중요적진단개치.
Objective To analyze the characteristics,electroencephalographic(EEG)features,neuroimaging findings,therapeutic effects and prognoses of 114 cases of idiopathic nocturnal frontal lobe epilepsy (NFLE). Methods The clinical data of 114 patients with idiopathic NHLE admitted in the epilepsy outpatient department from June,1999 to January,2007 were collected and analyzed. Results Idiopathic NFLE was clinically characterized by nocturnal clustered,postural or dystonic seizures and complex motor activities.The interictal routine EEG in 22.9% and dynamic EEG in 28% of the cases in wakefuIness and the interictal dynamic EEG in 38% of tbe cases in sleep showed frontal lobe epileptiform discharge,which was found in the EEG during seizure attacks in66.7% of the cases.Drug therapy was effeclive in 79.8% of the cases.with 29.7% of the cases showing complete seizure control. Conclusions Idiopathic NFLE has distinct clinical features wim relatively low rate of EEG abnormality during seizure attack or the interictal period.Frontal lobe epilepsy is more likely to occur in sleep,and sleep EEG is therefore of much importance in the diagnosis of idiopathic NFLE.