中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2012年
2期
127-130
,共4页
朱铁楠%赵永强%丁秋兰%白霞%王晓燕%王学锋%杨仁池%王兆钺%华宝来%魏旭倩%阮长耿%Nicole Schlegel
硃鐵楠%趙永彊%丁鞦蘭%白霞%王曉燕%王學鋒%楊仁池%王兆鉞%華寶來%魏旭倩%阮長耿%Nicole Schlegel
주철남%조영강%정추란%백하%왕효연%왕학봉%양인지%왕조월%화보래%위욱천%원장경%Nicole Schlegel
蛋白C%蛋白S%抗凝血酶
蛋白C%蛋白S%抗凝血酶
단백C%단백S%항응혈매
Protein C%Protein S%Antithrombin
目的 探讨蛋白C(PC)、蛋白S(PS)和抗凝血酶(AT)活性水平在中国汉族健康人群中的分布及其影响因素,观察此3种天然抗凝蛋白缺乏的发生率.方法 国内四家医学中心参加此研究,采集汉族健康献血员或常规体检者的外周静脉血标本,分别测定血浆PC、AT和PS的活性,前两者采用发色底物法,后者采用凝固法.结果 共募集3493名汉族志愿者.女性人群血浆PS和PC活性低于男性人群,以PS活性尤为显著(P ＜0.01);PC活性在不同性别人群均随年龄增长而增加,但在50岁后的男性人群中则呈下降趋势;PS活性在50岁前的人群中随年龄的变化不明显,但在50岁后的男性和女性人群中分别呈下降和上升趋势;AT活性在女性人群随年龄增长而逐步增加,而在50岁后男性人群明显下降.根据年龄和性别,PC、PS和AT缺乏的总发生率分别为1.15％、1.49％和2.29％.结论 在中国汉族健康人群中,PC、PS和AT的活性水平受年龄和性别的影响明显,应根据年龄和性别制定参考值范围和判断是否存在活性缺陷.
目的 探討蛋白C(PC)、蛋白S(PS)和抗凝血酶(AT)活性水平在中國漢族健康人群中的分佈及其影響因素,觀察此3種天然抗凝蛋白缺乏的髮生率.方法 國內四傢醫學中心參加此研究,採集漢族健康獻血員或常規體檢者的外週靜脈血標本,分彆測定血漿PC、AT和PS的活性,前兩者採用髮色底物法,後者採用凝固法.結果 共募集3493名漢族誌願者.女性人群血漿PS和PC活性低于男性人群,以PS活性尤為顯著(P ＜0.01);PC活性在不同性彆人群均隨年齡增長而增加,但在50歲後的男性人群中則呈下降趨勢;PS活性在50歲前的人群中隨年齡的變化不明顯,但在50歲後的男性和女性人群中分彆呈下降和上升趨勢;AT活性在女性人群隨年齡增長而逐步增加,而在50歲後男性人群明顯下降.根據年齡和性彆,PC、PS和AT缺乏的總髮生率分彆為1.15％、1.49％和2.29％.結論 在中國漢族健康人群中,PC、PS和AT的活性水平受年齡和性彆的影響明顯,應根據年齡和性彆製定參攷值範圍和判斷是否存在活性缺陷.
목적 탐토단백C(PC)、단백S(PS)화항응혈매(AT)활성수평재중국한족건강인군중적분포급기영향인소,관찰차3충천연항응단백결핍적발생솔.방법 국내사가의학중심삼가차연구,채집한족건강헌혈원혹상규체검자적외주정맥혈표본,분별측정혈장PC、AT화PS적활성,전량자채용발색저물법,후자채용응고법.결과 공모집3493명한족지원자.녀성인군혈장PS화PC활성저우남성인군,이PS활성우위현저(P ＜0.01);PC활성재불동성별인군균수년령증장이증가,단재50세후적남성인군중칙정하강추세;PS활성재50세전적인군중수년령적변화불명현,단재50세후적남성화녀성인군중분별정하강화상승추세;AT활성재녀성인군수년령증장이축보증가,이재50세후남성인군명현하강.근거년령화성별,PC、PS화AT결핍적총발생솔분별위1.15％、1.49％화2.29％.결론 재중국한족건강인군중,PC、PS화AT적활성수평수년령화성별적영향명현,응근거년령화성별제정삼고치범위화판단시부존재활성결함.
Objective To explore the distribution and infuence factors of protein C (PC),protein S (PS) and antithombin (AT) activities and to determine the prevalence of their deficiencies in the Chinese Han healthy population. Methods Healthy volunteers including blood donors and individuals for routine check-up were recruited from 4 Chinese medical centers.The plasma levels of PC,PS and AT activities were measured.The plasma levels of activities were measured by chromogenic substrate assay ( AT and PC) and clotting assay (PS).Results A total of 3493 healthy Chinese adults had been recruited in this study.Males had higher PS and PC activities than females,especially for PS (P ＜ 0.01 ).PC activities increased with age in both sexes but decreased in men after 50 years old.There was no significant change with age were of PS in 50 years old,while there was a decline in males and a rise in females above 50 years old.AT tended to increase with age in women but decreased with age in men after 50 years old.Based on the age and gender,the general prevalence of PC,PS and AT deficiencies in the general Chinese Han population were 1.15％,1.49％ and 2.29％,respectively.Conclusion PC,PS and AT activities have correlation with age and gender in Chinese Han poputation.Reference range should be laid down and deficiencies should be identified based on age and gender.
