肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
7期
463-465
,共3页
朱静娟%齐卫卫%邱文生%丁爱萍
硃靜娟%齊衛衛%邱文生%丁愛萍
주정연%제위위%구문생%정애평
胃肠肿瘤%抗肿瘤联合化疗方案%外周神经毒性%贫血
胃腸腫瘤%抗腫瘤聯閤化療方案%外週神經毒性%貧血
위장종류%항종류연합화료방안%외주신경독성%빈혈
Gastrointestinal neoplasms%Antineoplastic combined chemotherapy protocols%Peripheral neurotoxicity%Anemia
目的 观察左卡尼汀对胃肠肿瘤LFP方案化疗不良反应的防治作用.方法 60例胃肠肿瘤交替入两组,治疗组采用左卡尼汀加LFP方案化疗,对照组采用单纯LFP方案化疗.2组患者均化疗3个周期,对其胃肠道毒性、神经毒性、血液学毒性、体能状态进行比较.结果 治疗组发生外周神经毒性12例(40.0％),对照组发生21例(70.0％),两组差异有统计学意义(x2=5.4545,P=0.0195).治疗组发生贫血17例(56.7％),对照组发生26例(86.7％),两组差异有统计学意义(x2=6.698,P=0.0351).治疗组化疗后Karnofsky评分增加≥10分4例,Karnofsky评分未变化19例,Karnofsky评分减少≥10分7例；对照组Karnofsky评分增加≥10分1例,Karnofsky评分未变化13例,Karnofsky评分减少≥10分16例；两组患者化疗后体能状态变化的差异有统计学意义(x2=5.711,P=0.0169).两组胃肠道毒性、血小板减少和中性粒细胞减少差异无统计学意义.结论 左卡尼汀能减轻LFP方案化疗的外周神经毒性和血液学毒性,改善患者的体能状态.
目的 觀察左卡尼汀對胃腸腫瘤LFP方案化療不良反應的防治作用.方法 60例胃腸腫瘤交替入兩組,治療組採用左卡尼汀加LFP方案化療,對照組採用單純LFP方案化療.2組患者均化療3箇週期,對其胃腸道毒性、神經毒性、血液學毒性、體能狀態進行比較.結果 治療組髮生外週神經毒性12例(40.0％),對照組髮生21例(70.0％),兩組差異有統計學意義(x2=5.4545,P=0.0195).治療組髮生貧血17例(56.7％),對照組髮生26例(86.7％),兩組差異有統計學意義(x2=6.698,P=0.0351).治療組化療後Karnofsky評分增加≥10分4例,Karnofsky評分未變化19例,Karnofsky評分減少≥10分7例；對照組Karnofsky評分增加≥10分1例,Karnofsky評分未變化13例,Karnofsky評分減少≥10分16例；兩組患者化療後體能狀態變化的差異有統計學意義(x2=5.711,P=0.0169).兩組胃腸道毒性、血小闆減少和中性粒細胞減少差異無統計學意義.結論 左卡尼汀能減輕LFP方案化療的外週神經毒性和血液學毒性,改善患者的體能狀態.
목적 관찰좌잡니정대위장종류LFP방안화료불량반응적방치작용.방법 60례위장종류교체입량조,치료조채용좌잡니정가LFP방안화료,대조조채용단순LFP방안화료.2조환자균화료3개주기,대기위장도독성、신경독성、혈액학독성、체능상태진행비교.결과 치료조발생외주신경독성12례(40.0％),대조조발생21례(70.0％),량조차이유통계학의의(x2=5.4545,P=0.0195).치료조발생빈혈17례(56.7％),대조조발생26례(86.7％),량조차이유통계학의의(x2=6.698,P=0.0351).치료조화료후Karnofsky평분증가≥10분4례,Karnofsky평분미변화19례,Karnofsky평분감소≥10분7례；대조조Karnofsky평분증가≥10분1례,Karnofsky평분미변화13례,Karnofsky평분감소≥10분16례；량조환자화료후체능상태변화적차이유통계학의의(x2=5.711,P=0.0169).량조위장도독성、혈소판감소화중성립세포감소차이무통계학의의.결론 좌잡니정능감경LFP방안화료적외주신경독성화혈액학독성,개선환자적체능상태.
Objective To observe the efficacy of L-carnitine in prevention and treatment of toxicity of LFP chemotherapy with gastrointestinal cancer. Methods 60 cases of gastrointestinal cancer were divided into 2 groups according to the admission date. The treatment groups received LFP chemotherapy and L-carnitine, while the control group received LFP chemotherapy alone. Both groups received 3 cycles chemotherapy. The gastrointestinal toxicity, neurotoxicity, hematologic toxicity and physical state were compared.Results There were 12 cases of peripheral neurotoxicity in treatment group,the incidence rate was 40.0 ％; but in control group there were 21 patients, and the incidence rate was 70.0 ％. There was a significant difference between the two groups (x2=5.4545,P =0.0195). Anemia in the treatment group was 56.7 ％ (17/30); in the control group the rate was 86.7 ％ (26/30).There was a significant difference between the two groups (x2 =6.698,P =0.0351).After chemotherapy,in the treatment group,there were 4 cases with increasing Karnofsky score ≥ 10,19 patients whose Karnofsky score did not change,and 7 cases with reduced Karnofsky score ≥ 10; in the control group,there was 1 case with increasing Karnofsky score ≥ 10,13 cases with Karnofsky score no changing,and 16 cases with reduced Karnofsky score ≥ 10.The changes in physical state of two groups had a significant difference (x2 =5.711,P =0.0169). The gastrointestinal toxicity,thrombocytopenia,and neutropenia of two groups had no significant difference.Conclusion L-carnitine can reduce peripheral neurotoxicity and hematologic toxicity, improve the patient's physical state in patients received LFP chemotherapy.
