CAJ | 학술논문

目的探讨重型地中海贫血患儿治疗依从性对患儿预后的影响.方法采取便利抽样的方法,应用依从指数、血清铁蛋白浓度(SF)等方法测量重型地中海贫血患儿的治疗依从性,研究患儿的治疗依从性与并发症发生率的关系.结果重型地中海贫血患儿的治疗依从性低,为22.12%(依从指数)和55.77%(SF),男女患儿之间的治疗依从性差异无统计学意义(P>0.05).治疗依从性低的患儿中并发症的发生率为85.19%(依从指数)和100.00%(SF),其中心脏并发症为60.49%(依从指数)和84.78%(SF),肝脏并发症为46.91%(依从指数)和76.09%(SF),感染并发症8.64%(依从指数)和10.86%(SF),生长发育障碍并发症为55.56%(依从指数)和67.39%(SF),贫血并发症为43.21%(依从指数)和21.74%(SF).治疗依从性好的患儿并发症的发生率低于治疗依从性差的患儿(P<0.01).结论重型地中海贫血患儿的治疗依从性低,并发症的发生率高.治疗依从性低可增加并发症的发生率.
목적 탐토중형지중해빈혈환인치료의종성대환인예후적영향.방법 채취편리추양적방법,응용의종지수、혈청철단백농도(SF)등방법측량중형지중해빈혈환인적치료의종성,연구환인적치료의종성여병발증발생솔적관계.결과 중형지중해빈혈환인적치료의종성저,위22.12%(의종지수)화55.77%(SF),남녀환인지간적치료의종성차이무통계학의의(P>0.05).치료의종성저적환인중병발증적발생솔위85.19%(의종지수)화100.00%(SF),기중심장병발증위60.49%(의종지수)화84.78%(SF),간장병발증위46.91%(의종지수)화76.09%(SF),감염병발증8.64%(의종지수)화10.86%(SF),생장발육장애병발증위55.56%(의종지수)화67.39%(SF),빈혈병발증위43.21%(의종지수)화21.74%(SF).치료의종성호적환인병발증적발생솔저우치료의종성차적환인(P<0.01).결론 중형지중해빈혈환인적치료의종성저,병발증적발생솔고.치료의종성저가증가병발증적발생솔.
Objective The purpose of this study was to describe the influence of therapy compliance on prognosis of children with thalassaemia major (TM). Methods Children with TM was recruited by convenient sampling. The therapy compliance was measured by compliance index (CI) and serum ferritin (SF), The correlation between therapy compliance and incidence of complications were studied. Results Low therapy compliance existed in children with TM, 22.12% (CI) and 55.77% (SF). But no statistical difference existed in therapy compliance between boys and girls (P>0.05). Complication incidence in children with low therapy compliance was 85.19% (CI) and 100.00% (SF). The incidence of cardiac complication was 60.49% (CI) and 84.78% (SF), hepatic complication was 46.91% (CI) and 76.09% (SF), infectious complication was 8.64% (CI) and 10.86% (SF), growth retardation complication was 55.56% (CI) and 67.39% (SF), anemia complication was 43.21% (CI) and 21.74% (SF). The incidence rate of complications was lower in children with better therapy compliance than those with worse therapy compliance (P<0.01). Conclusions Children with TM had low therapy compliance and high incidence rate of complications. Low therapy increased the incidence rate of complications.