CAJ | 학술논문

淋巴细胞染色体畸变率与电离辐射密切相关,并且已经广泛应用于辐射损伤的生物剂量评估.多色荧光原位杂交显带技术(mBAND)是染色体畸变检测的重要新兴技术,并且逐步应用于不同传能线密度(LET)射线所引起的染色体畸变检测.该文对mBAND技术在X、γ射线所属的低LET射线和太空射线及高能重离子流所属的高LET射线中的应用,二者引起不同染色体畸变类型以及产生的不同辐射生物剂量效能作综合阐述.
림파세포염색체기변솔여전리복사밀절상관,병차이경엄범응용우복사손상적생물제량평고.다색형광원위잡교현대기술(mBAND)시염색체기변검측적중요신흥기술,병차축보응용우불동전능선밀도(LET)사선소인기적염색체기변검측.해문대mBAND기술재X、γ사선소속적저LET사선화태공사선급고능중리자류소속적고LET사선중적응용,이자인기불동염색체기변류형이급산생적불동복사생물제량효능작종합천술.
Lymphocyte chromosome aberrations rate is closely related with ionizing radiation,and it has been widely used in biological dose evaluating.Multicolour-banding fluorescence in situ hybridisation(mBAND) is a newly-emerging technology in chromosome aberrations checking.It has been used in chromosome aberrations checking of different linear energy transfer(LET) rays.This article briefly reviewed mBAND using in different chromosome aberrations checking and different radiation biological evaluation by both low LET(such as X and /rays) and high LET(such as space lines and energetic heavy ions).