CAJ | 학술논문

目的探讨血清一氧化氮水平与微量蛋白尿的关联性.方法以苏州市金阊区的高血压现场调查为基础,采用1∶2配对研究方法,选择208例微量蛋白尿患者及与之在性别、年龄、血糖和腰围相匹配的居住同一小区、同等经济收入水平的非微量蛋白尿人群,测量血清一氧化氮水平,采用多因素条件logistic回归对血清一氧化氮水平与微量蛋白尿的关联性进行分析.结果微量蛋白尿组的血清一氧化氮水平略低于非微量蛋白尿组(中位数,四分位间距:27.75,14.48～ 42.15μmol/L vs.28.25,17.40～ 43.45μmol/L),但两组间差异无统计学意义(P=0.316).多因素条件logistic回归分析显示,调整血压、血脂、尿酸、吸烟、饮酒后,血清一氧化氮水平与微量蛋白尿不存在显著关联性.进一步按是否患高血压分层,多因素条件logistic回归分析显示,与血清一氧化氮水平最高分位者相比,在多因素调整后,无论是在高血压还是非高血压的对子中,血清一氧化氮水平处于第1、2、3分位者患微量蛋白尿的危险性差异均无统计学意义.在有高血压的对子中,血清一氧化氮最低水平组患有微量蛋白尿的危险性是最高水平组的1.85倍(OR=1.85,95％CI:0.96～ 3.57);而在非高血压的对子中,血清一氧化氮最低水平组患有微量蛋白尿的危险性较最高水平组仅增加了40％(OR=1.40,95％CI:0.58 ～ 3.40).结论在一般人群中,血清一氧化氮水平与微量蛋白尿无显著相关性.
목적 탐토혈청일양화담수평여미량단백뇨적관련성.방법 이소주시금창구적고혈압현장조사위기출,채용1∶2배대연구방법,선택208례미량단백뇨환자급여지재성별、년령、혈당화요위상필배적거주동일소구、동등경제수입수평적비미량단백뇨인군,측량혈청일양화담수평,채용다인소조건logistic회귀대혈청일양화담수평여미량단백뇨적관련성진행분석.결과 미량단백뇨조적혈청일양화담수평략저우비미량단백뇨조(중위수,사분위간거:27.75,14.48～ 42.15μmol/L vs.28.25,17.40～ 43.45μmol/L),단량조간차이무통계학의의(P=0.316).다인소조건logistic회귀분석현시,조정혈압、혈지、뇨산、흡연、음주후,혈청일양화담수평여미량단백뇨불존재현저관련성.진일보안시부환고혈압분층,다인소조건logistic회귀분석현시,여혈청일양화담수평최고분위자상비,재다인소조정후,무론시재고혈압환시비고혈압적대자중,혈청일양화담수평처우제1、2、3분위자환미량단백뇨적위험성차이균무통계학의의.재유고혈압적대자중,혈청일양화담최저수평조환유미량단백뇨적위험성시최고수평조적1.85배(OR=1.85,95％CI:0.96～ 3.57);이재비고혈압적대자중,혈청일양화담최저수평조환유미량단백뇨적위험성교최고수평조부증가료40％(OR=1.40,95％CI:0.58 ～ 3.40).결론재일반인군중,혈청일양화담수평여미량단백뇨무현저상관성.
Objective To investigate the association betweenserum nitric oxide and microalbuminuria.Methods Based on a community survey in Jinchang district Suzhou city,a 1 ∶ 2 matched case-control study was performed.A total of 208 cases with microalbuminuria were recruited.The controls were selected from the same community,with the same level of income.After matched with age,gender,waist circumference and fast plasma glucose,a total of 416 controls were selected.Values of serum nitric oxide were tested for all eligible participants.The association between serum nitric oxide level and microalbuminuria were analyzed by using the multivariate conditional logistic regression models.Results The mean level of serum nitric oxide was slightly lower for individuals with microalbuminuria (median,interquartile range:27.75,14.48-42.15 μmol/L) than those without (28.25,17.40-43.45 μ mol/L ).However,the difference was not statistically significant (P=0.316).Results from the multivariable conditional logistic regression model showed that serum nitric oxide level was not associated with microalbuminuria,after adjustment for all the confounders.Compared with the highest level of serum nitric oxide,the odds ratios of microalbuminuria for individuals in the 1 st,2nd and 3rd quartiles were not significantly different,after adjustment for confounders.In pairs with hypertension,the odds of microalbuminuria were 85％ higher for individuals with the lowest level of serum nitric oxide than those with the highest level (OR=1.85,95％ CI:0.96-3.57).Additionally,in pairs without hypertension,the odds of microalbuminuria was just 40％ higher for individuals with the lowest level of serum nitric oxide than those with the highest level (OR=1.40,95％CI:0.58-3.40).Conclusion There was no significant correlation between serum nitric oxide and microalbuminuria in the general population in our study.