中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2008年
5期
542-545
,共4页
王辉%王春慧%冯铁建%周华%李丽雄%王蜂%赵广录%朱托夫%周伯平
王輝%王春慧%馮鐵建%週華%李麗雄%王蜂%趙廣錄%硃託伕%週伯平
왕휘%왕춘혜%풍철건%주화%리려웅%왕봉%조엄록%주탁부%주백평
DC-SIGNR基因%人类免疫缺陷病毒-1%遗传多态性%基因型
DC-SIGNR基因%人類免疫缺陷病毒-1%遺傳多態性%基因型
DC-SIGNR기인%인류면역결함병독-1%유전다태성%기인형
DC-SIGNR gene%human immunodeficiency vires-1%genetic polymorphisms%genotype
目的 探索DC-SIGNR基因多态性对中国汉族人群人类免疫缺陷病毒-1(human immunodeficiency virus-1,HIV-1)病毒易感性的影响.方法 用聚合酶链反应、琼脂糖凝胶电泳结合测序对345例HIV-1血清阳性感染者及468例H1V-1血清阴性高危人群的DC-SIGNR基因绞链区重复序列分型,然后用卡方检验检测DC-SIGNR基因各亚型在不同人群组中出现的频率.结果 共发现DC-SIGNR基因14个基因型和5种等位基因,其中等位基因7出现的频率最高(67.1%),明显高于美国白人(67.1% vs.46.0%,P<0.01).HIV-1感染组7/7基因型的出现频率明显低于高危人群组(38.55% vs.48.29%,P=0.0057),而HIV-1感染组的9/5基因型的出现频率明显高于高危人群组(4.35% vs.1.07%,P=0.0029).结论 中国人群DC-SIGNR基因多态性分布有着独特的遗传学特征,中国人群中DC-SIGNR基因型9/5可能增加对HIV-1的易感性.
目的 探索DC-SIGNR基因多態性對中國漢族人群人類免疫缺陷病毒-1(human immunodeficiency virus-1,HIV-1)病毒易感性的影響.方法 用聚閤酶鏈反應、瓊脂糖凝膠電泳結閤測序對345例HIV-1血清暘性感染者及468例H1V-1血清陰性高危人群的DC-SIGNR基因絞鏈區重複序列分型,然後用卡方檢驗檢測DC-SIGNR基因各亞型在不同人群組中齣現的頻率.結果 共髮現DC-SIGNR基因14箇基因型和5種等位基因,其中等位基因7齣現的頻率最高(67.1%),明顯高于美國白人(67.1% vs.46.0%,P<0.01).HIV-1感染組7/7基因型的齣現頻率明顯低于高危人群組(38.55% vs.48.29%,P=0.0057),而HIV-1感染組的9/5基因型的齣現頻率明顯高于高危人群組(4.35% vs.1.07%,P=0.0029).結論 中國人群DC-SIGNR基因多態性分佈有著獨特的遺傳學特徵,中國人群中DC-SIGNR基因型9/5可能增加對HIV-1的易感性.
목적 탐색DC-SIGNR기인다태성대중국한족인군인류면역결함병독-1(human immunodeficiency virus-1,HIV-1)병독역감성적영향.방법 용취합매련반응、경지당응효전영결합측서대345례HIV-1혈청양성감염자급468례H1V-1혈청음성고위인군적DC-SIGNR기인교련구중복서렬분형,연후용잡방검험검측DC-SIGNR기인각아형재불동인군조중출현적빈솔.결과 공발현DC-SIGNR기인14개기인형화5충등위기인,기중등위기인7출현적빈솔최고(67.1%),명현고우미국백인(67.1% vs.46.0%,P<0.01).HIV-1감염조7/7기인형적출현빈솔명현저우고위인군조(38.55% vs.48.29%,P=0.0057),이HIV-1감염조적9/5기인형적출현빈솔명현고우고위인군조(4.35% vs.1.07%,P=0.0029).결론 중국인군DC-SIGNR기인다태성분포유착독특적유전학특정,중국인군중DC-SIGNR기인형9/5가능증가대HIV-1적역감성.
Objective To explore the association of the polymorphism of homologue of dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN related, DC-SIGNR) gene with the susceptibility to HIV-1 infection. Methods The distribution of the DC-SIGNR variants in the tandem repeat region and their association with HIV-1 infection in a cohort composed of 345 HIV-1 seropositive and 468 high-risk HIV-1 seronegative individuals was examined. Results There are 14 genotypes and 5 alleles in the DC-SIGNR repeat regions in the cohort.Although the most common DC-SIGNR allele among Chinese Han population and the Caucasian population is 7, it was found in a higher frequency in the Chinese than in Caucasians (67.1% vs.46.0%, P <0.01 ). HIV-1 seropositive individuals had a lower frequency of the genotype 7/7 than the high-risk seronegative individuals (38.55 % vs.48.29%,P =0.0057), bui a higher frequency of genotype 9/5 (4.35% vs.1.07%, P =0.0029). ConclusionThese results suggest that the tandem-repeat polymorphisms of the DC-SIGNR gene in the Chinese Han population exhibit unique genetic characteristics previously unrecognized in the Caucasian population. Genotype 9/5 seems to be a risk factor for HIV-1 infection in the Chinese population.
