CAJ | 학술논문

目的:从中医整体观的角度探索高血压、糖尿病及高脂血症在发病机制上的相关性.资料来源:应用计算机检索Medline 1985-01/2004-12关于高血压、糖尿病、高脂血症发病机制的文章,检索词"hypertension,diabetes,hy-perlipemia,pathogenesis",并限定语言种类为English.同时检索中国期刊全文数据库1990-01/2004-12关于高血压、糖尿病、高脂血症发病机制的文章,限定文章语言种类为中文,检索词"高血压、糖尿病、高脂血症、发病机制".资料选择:对资料进行初审,选取高血压病、糖尿病、高脂血症的中医病因病机及现代医学发病机制的文献.纳入标准为①随机对照临床试验,采用单盲、双盲或非盲法.②非随机对照试验.③前后对照试验研究.④专著中的章节.排除标准:排除重复性研究.资料提炼:共收集到28篇关于高血压病、糖尿病、高脂血症的中医病因病机及现代医学发病机制的文章,其中12篇符合纳入标准.排除的16篇均为重复性文章.资料综合:对12篇关于中医及现代医学对高血压病、糖尿病、高脂血症的发病机制的认识文章进行分析,并从分子生物学的角度提示这3种疾病的内在联系.结论:设想把这3种疾病当成一个整体来加以研究.把高血压、高血糖、高血脂看成是这一整体的不同表现形式,或者是这一整体的不同发展过程,在某一病程中可以某一形式为突出表现.可以是以高血压为主要临床表现,或者是高血糖、或者是高血脂为主要临床表现,也可表现为几种形式共存.认为在现代医学研究中借鉴中医的整体观和脏腑理论将会是有益的尝试.
목적:종중의정체관적각도탐색고혈압、당뇨병급고지혈증재발병궤제상적상관성.자료래원:응용계산궤검색Medline 1985-01/2004-12관우고혈압、당뇨병、고지혈증발병궤제적문장,검색사"hypertension,diabetes,hy-perlipemia,pathogenesis",병한정어언충류위English.동시검색중국기간전문수거고1990-01/2004-12관우고혈압、당뇨병、고지혈증발병궤제적문장,한정문장어언충류위중문,검색사"고혈압、당뇨병、고지혈증、발병궤제".자료선택:대자료진행초심,선취고혈압병、당뇨병、고지혈증적중의병인병궤급현대의학발병궤제적문헌.납입표준위①수궤대조림상시험,채용단맹、쌍맹혹비맹법.②비수궤대조시험.③전후대조시험연구.④전저중적장절.배제표준:배제중복성연구.자료제련:공수집도28편관우고혈압병、당뇨병、고지혈증적중의병인병궤급현대의학발병궤제적문장,기중12편부합납입표준.배제적16편균위중복성문장.자료종합:대12편관우중의급현대의학대고혈압병、당뇨병、고지혈증적발병궤제적인식문장진행분석,병종분자생물학적각도제시저3충질병적내재련계.결론:설상파저3충질병당성일개정체래가이연구.파고혈압、고혈당、고혈지간성시저일정체적불동표현형식,혹자시저일정체적불동발전과정,재모일병정중가이모일형식위돌출표현.가이시이고혈압위주요림상표현,혹자시고혈당、혹자시고혈지위주요림상표현,야가표현위궤충형식공존.인위재현대의학연구중차감중의적정체관화장부이론장회시유익적상시.
OBJECTIVE: According to the holism in traditional Chinese medicine (TCM) theory, this manuscript explores the relativity of pathogenesis among hypertension, diabetes and hyperlipemia.DATA SOURCES: We applied computer to search articles in English on pathogenesis ofhypertension, diabetes and hyperlipemia in Medline between January 1985 and December 2004 by words "hypertension, diabetes, hyperlipemia, pathogenesis" .Besides, we also used computer to search articles in Chinese on pathogenesis of hypertension, diabetes and hyperlipemia in Chinese magazine full text database between January 1990 and December 2004 by words "hypertension, diabetes, hyperlipemia, pathogenesis".STUDY SELECTION: Primarily, articles on pathogenesis of hypertension,diabetes and hyperlipemia were selected in TCM and modern medicine respectively. Accepted standard were: ① Random control clinic test with methods of single blind, double blind or no blind; ② Nonrandom control test;③ Fore-and-aft control test; ④ Chapter in monograph. Eliminated standard:repeated research.DATA EXTRACTION: Totally 28 articles on pathogenesis of hypertension,diabetes and hyperlipemia were found in TCM and modern medicine, however, 12 articles were selected according to accepted standard, and 16 articles were eliminated due to repeated content.DATA SYSTHESIS: Totally 12 selected articles were analyzed on pathogeneses of hypertension, diabetes and hyperlipemia in TCM and modern medicine, and hinted internal affiliation of these three diseases from view of molecular biology.CONCLUSION: These three diseases can be regarded as a whole entity for study. High blood pressure, high blood sugar and high lipemia could be treated as different forms of the entity or in different developing courses of the whole. In a certain course it might present as one of the forms specifically. It might manifest high blood pressure mainly in clinic, or high blood sugar, or high lipemia,also several forms at the same time. It will be beneficial to take the holism and visceral theory in TCM for reference in research of modern medicine.