中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2007年
48期
9809-9812
,共4页
蔺嫦燕%吴广辉%李冰一%侯晓彤%王景%周响乐%潘红九
藺嫦燕%吳廣輝%李冰一%侯曉彤%王景%週響樂%潘紅九
린항연%오엄휘%리빙일%후효동%왕경%주향악%반홍구
血液相容性%国产%轴流血泵
血液相容性%國產%軸流血泵
혈액상용성%국산%축류혈빙
背景:轴流式血泵是用于心室辅助的主要泵型.前期大量研究结果表明血泵内的不良血液流动特性是导致溶血和血栓的重要因素.目的:在前期轴流血泵的设计图基础上,利用计算机优化技术和计算流体力学的方法,通过改变血泵整体形态及叶轮形状设计一轴流血泵,并装配成型.设计:采用加工后实际测试验证理论设计的合理性.单位:首都医科大学附属北京安贞医院-北京心肺血管疾病研究所生物医学工程研究室与中国航天科技集团总公司北京十四所.材料:血泵泵体及叶轮为钛合金材料,轴承为陶瓷轴承.体外测试用首都医科大学附属北京安贞医院生物医学工程研究室的人工心室辅助装置试验测试台.实验用羊由首都医科大学附属北京安贞医院实验动物房提供.方法:于2005年初开始,首先在中国航天科技集团总公司北京十四所,利用计算机优化技术和计算流体力学技术,基于最大限度减小剪切力和减少流动死区的原则基础上设计血泵的整体形态、叶轮数目和形状、导叶轮的结构和位置以及叶轮的螺距.然后使用数控机床加工成型.最后将轴流血泵安装到首都医科大学附属北京安贞医院生物医学工程研究室的人工心室辅助装置试验测试台上,在输出条件为5 L/min流量和13.3 kPa压力,流体介质为甘油和水混合液以及新鲜抗凝羊血的条件下,血泵运转4 h,每隔0.5 h取血样标本.这样通过测试血泵的压力流量输出,以标准溶血指数反映血浆中游离血红蛋白含量,观察泵内血栓形成情况验证血泵的动力学输出性能及血液破坏程度.结果:加工成型后的轴流血泵为泵-机一体结构,包括泵体、叶轮、导叶轮、陶瓷轴承以及进出口等,容积63mL.体外实验结果证实,当血泵运转速度为10 000 r/min时,它的压力、流量输出为21.01 kPa和6.0 L/min,其动力学输出性能可以满足患者左心辅助需求,血泵连续运转时其表面温度变化不明显.计算流场显示血泵的内部大多呈层流状态,血泵的体外测试标准溶血指数为(0.047±0.017) g/100 L,此数值远远低于以前的轴流血泵,且在血泵内部没有任何血栓形成.结论:经过CAD和CFD方法设计的轴流血泵,在满足左心辅助的压力、流量输出要求同时,血液破坏程度远远小于以前的轴流血泵,提高了轴流血泵的血液相容性.
揹景:軸流式血泵是用于心室輔助的主要泵型.前期大量研究結果錶明血泵內的不良血液流動特性是導緻溶血和血栓的重要因素.目的:在前期軸流血泵的設計圖基礎上,利用計算機優化技術和計算流體力學的方法,通過改變血泵整體形態及葉輪形狀設計一軸流血泵,併裝配成型.設計:採用加工後實際測試驗證理論設計的閤理性.單位:首都醫科大學附屬北京安貞醫院-北京心肺血管疾病研究所生物醫學工程研究室與中國航天科技集糰總公司北京十四所.材料:血泵泵體及葉輪為鈦閤金材料,軸承為陶瓷軸承.體外測試用首都醫科大學附屬北京安貞醫院生物醫學工程研究室的人工心室輔助裝置試驗測試檯.實驗用羊由首都醫科大學附屬北京安貞醫院實驗動物房提供.方法:于2005年初開始,首先在中國航天科技集糰總公司北京十四所,利用計算機優化技術和計算流體力學技術,基于最大限度減小剪切力和減少流動死區的原則基礎上設計血泵的整體形態、葉輪數目和形狀、導葉輪的結構和位置以及葉輪的螺距.然後使用數控機床加工成型.最後將軸流血泵安裝到首都醫科大學附屬北京安貞醫院生物醫學工程研究室的人工心室輔助裝置試驗測試檯上,在輸齣條件為5 L/min流量和13.3 kPa壓力,流體介質為甘油和水混閤液以及新鮮抗凝羊血的條件下,血泵運轉4 h,每隔0.5 h取血樣標本.這樣通過測試血泵的壓力流量輸齣,以標準溶血指數反映血漿中遊離血紅蛋白含量,觀察泵內血栓形成情況驗證血泵的動力學輸齣性能及血液破壞程度.結果:加工成型後的軸流血泵為泵-機一體結構,包括泵體、葉輪、導葉輪、陶瓷軸承以及進齣口等,容積63mL.體外實驗結果證實,噹血泵運轉速度為10 000 r/min時,它的壓力、流量輸齣為21.01 kPa和6.0 L/min,其動力學輸齣性能可以滿足患者左心輔助需求,血泵連續運轉時其錶麵溫度變化不明顯.計算流場顯示血泵的內部大多呈層流狀態,血泵的體外測試標準溶血指數為(0.047±0.017) g/100 L,此數值遠遠低于以前的軸流血泵,且在血泵內部沒有任何血栓形成.結論:經過CAD和CFD方法設計的軸流血泵,在滿足左心輔助的壓力、流量輸齣要求同時,血液破壞程度遠遠小于以前的軸流血泵,提高瞭軸流血泵的血液相容性.
배경:축류식혈빙시용우심실보조적주요빙형.전기대량연구결과표명혈빙내적불량혈액류동특성시도치용혈화혈전적중요인소.목적:재전기축류혈빙적설계도기출상,이용계산궤우화기술화계산류체역학적방법,통과개변혈빙정체형태급협륜형상설계일축류혈빙,병장배성형.설계:채용가공후실제측시험증이론설계적합이성.단위:수도의과대학부속북경안정의원-북경심폐혈관질병연구소생물의학공정연구실여중국항천과기집단총공사북경십사소.재료:혈빙빙체급협륜위태합금재료,축승위도자축승.체외측시용수도의과대학부속북경안정의원생물의학공정연구실적인공심실보조장치시험측시태.실험용양유수도의과대학부속북경안정의원실험동물방제공.방법:우2005년초개시,수선재중국항천과기집단총공사북경십사소,이용계산궤우화기술화계산류체역학기술,기우최대한도감소전절력화감소류동사구적원칙기출상설계혈빙적정체형태、협륜수목화형상、도협륜적결구화위치이급협륜적라거.연후사용수공궤상가공성형.최후장축류혈빙안장도수도의과대학부속북경안정의원생물의학공정연구실적인공심실보조장치시험측시태상,재수출조건위5 L/min류량화13.3 kPa압력,류체개질위감유화수혼합액이급신선항응양혈적조건하,혈빙운전4 h,매격0.5 h취혈양표본.저양통과측시혈빙적압력류량수출,이표준용혈지수반영혈장중유리혈홍단백함량,관찰빙내혈전형성정황험증혈빙적동역학수출성능급혈액파배정도.결과:가공성형후적축류혈빙위빙-궤일체결구,포괄빙체、협륜、도협륜、도자축승이급진출구등,용적63mL.체외실험결과증실,당혈빙운전속도위10 000 r/min시,타적압력、류량수출위21.01 kPa화6.0 L/min,기동역학수출성능가이만족환자좌심보조수구,혈빙련속운전시기표면온도변화불명현.계산류장현시혈빙적내부대다정층류상태,혈빙적체외측시표준용혈지수위(0.047±0.017) g/100 L,차수치원원저우이전적축류혈빙,차재혈빙내부몰유임하혈전형성.결론:경과CAD화CFD방법설계적축류혈빙,재만족좌심보조적압력、류량수출요구동시,혈액파배정도원원소우이전적축류혈빙,제고료축류혈빙적혈액상용성.
BACKGROUND: Axial-flow blood pump is a main pump for ventricle assistance. Previous researches demonstrate that poor hemocompatibility of blood pump is an important factor for hemolysis and thrombus.OBJ ECTTVE: To design an axial-flow blood pump based on previous kinds of blood pumps through changing whole appearance and impeller shape of the pump by using Computer-Aided Design CAD) and Computational Fluid Dynamics (CFD), and manufacture it successfully.DESIGN: Rationality of theoretical design was verified by practical tests.SETTTNG: Beijing Anzhen Hospital of Capital University of Medical Sciences Department of Biomedical Engineering,Beijing Institute of Heart, lung and Blood Vessel Diseases; the Faurteenth Institute of China-Aerospace Science and Industry Corporation.MATERIALS: Body of blood pump and impeller were titanium alligation, and shaft bearing was ceramic. Test in vitro was accorded to artificial ventricular assist device which was provided by Department of Biomedical Engineering, Beijing Anzhen Hospital of Capital University of Medical Sciences. Experimental goats were provided by Experimental Animal Center, Beijing Anzhen Hospital of Capital University of Medical Sciences.METHODS: Since the beginning of 2005, a model of axial flow blood pump was designed in the 14th Institute of China-Aerospace Science and Industry Corporation base on decreasing shearing force and circulating dead bands. In the process, CAD and CFD were used to generate the geometrical data document of pump's structure, which included the figures of pump's body, shape and number of impeller's vanes, the structure and position of the guide vanes, and the size of impeller's screw-pitch. And then, NC machine tool was used for shaping. Finally, axial-flow blood pump was fixed on artificial ventricular assist device which was provided by Department of Biomedical Engineering, Beijing Anzhen Hospital of Capital University of Medical Sciences. The pump's hemodynamic output was 5 L/min and the average pressure was 13.3 kPa under the mixture of glycerin and water and fresh anticoagulation goat blood. The samples were collected at every one half hour during pumps being pumping for 4 hours. According to testing pressure output of blood pump, normalized index of hemolysis (NIH) was used to reflect content of free hemoglobin in plasma, observe thrombogenesis in pump and verify pump's hemodynamic output and vascular damaging degree.RESULTS: Shaped axial-flow blood pump included body, impeller, guide vanes, ceramic shaft bearing, export and import. The volume was 63 mL. Experimental results in vitro indicated that when the rotation speed of blood pump was 10 000 r/min, its pressure and flow output were 21.01 kPa and 6.0 L/min. The hemodynamic output might satisfy for left ventricular assistance. Surface temperature did not change obviously during successive rotation. The calculation indicated that most parts in blood pump showed a streaming flow. The mean NIH was (0.047±0.017) g/100 L, which was less than that of previous pumps; while, thrombogenesis was not observed in blood pump.CONCLUSTON: Axial-flow blood pump designed by using CAD and CFD can not only satisfy for the hemodynamics of a left ventricular assistant devices, but also the blood damage is milder than previous pumps. Therefore, axial-flow blood pump improves blood compatibility.
