复旦学报（医学版）
複旦學報（醫學版）
복단학보（의학판）
FUDAN UNIVERSITY JOURNAL OF MEDICAL SCIENCES
2012年
1期
86-93
,共8页
抗青光眼药物%不良反应%眼表%防腐剂%预防措施
抗青光眼藥物%不良反應%眼錶%防腐劑%預防措施
항청광안약물%불량반응%안표%방부제%예방조시
antiglaucoma drugs%side effects%ocular surface%preservatives%prophylactic measures
抗青光眼药物是治疗开角型青光眼(primary oper-angle glancoma,POAG)的一线药物.此类药物在降低眼压的同时会对眼表结构(泪膜、结膜、角膜)产生一定的不良反应.药物中所含的防腐剂(如氯化苯甲烃铵)可能是引起不良反应的原因.无防腐剂药物、维生素A棕榈酸酯眼用凝胶及多种新型药物制剂如纳米乳化剂、阳离子乳化剂及抗代谢药物等都可以在一定程度上预防此类不良反应的发生.
抗青光眼藥物是治療開角型青光眼(primary oper-angle glancoma,POAG)的一線藥物.此類藥物在降低眼壓的同時會對眼錶結構(淚膜、結膜、角膜)產生一定的不良反應.藥物中所含的防腐劑(如氯化苯甲烴銨)可能是引起不良反應的原因.無防腐劑藥物、維生素A棕櫚痠酯眼用凝膠及多種新型藥物製劑如納米乳化劑、暘離子乳化劑及抗代謝藥物等都可以在一定程度上預防此類不良反應的髮生.
항청광안약물시치료개각형청광안(primary oper-angle glancoma,POAG)적일선약물.차류약물재강저안압적동시회대안표결구(루막、결막、각막)산생일정적불량반응.약물중소함적방부제(여록화분갑경안)가능시인기불량반응적원인.무방부제약물、유생소A종려산지안용응효급다충신형약물제제여납미유화제、양리자유화제급항대사약물등도가이재일정정도상예방차류불량반응적발생.
Antiglaucoma medications are the first line therapy for the patients with primary open-angle glaucoma (POAG).As these intraocular pressure (IOP)-lowering agents are used for spanning years,good tolerability and better compliance are desired.Long-term application of antiglaucoma medications may exert side effects on ocular surface,which includes tear film,conjunctiva and cornea.These side effects can be attributable to the preservatives contained in the eye drops,e.g.,benzalkonium chloride (BAK).Preservative-free eye drops,vitamin A palmitate,antimetabolites,and new drug deliveries such as nanoemulsions and cationic emulsions,can contribute to minimizing the side effects as well as promoting the compliance and continuation of medication therapy.
