CAJ | 학술논문

目的测定内分泌性眼病患者外周血中的细胞因子,包括血清白细胞介素6(IL-6),胰岛素样生长因子1(IGF-1)的水平变化,寻找IL-6及IGF-1与内分泌性眼病的发病情况以及病情变化的关系.方法 30例内分泌性眼病患者、30例无突眼甲亢患者、健康对照组30例,用放射免疫分析法分别对以上3组患者人血清IL-6、IGF-1进行测定.结果内分泌性眼病组患者血清IL-6、IGF-1的水平较无突眼的甲亢组(t=4.20、t=4.00,P＜0.01)和健康对照组0=420、t=4.05,P＜0.01)显著升高,而且IL-6、IGF-1的水平变化随内分泌性眼病患者眼病的分级程度增加而升高,均有显著性差异.结论外周血中IL-6、IGF-1水平与内分泌性眼病的发病密切相关,而且IL-6、IGF-1的水平与内分泌性眼病的严重程度呈正相关.
목적 측정내분비성안병환자외주혈중적세포인자,포괄혈청백세포개소6(IL-6),이도소양생장인자1(IGF-1)적수평변화,심조IL-6급IGF-1여내분비성안병적발병정황이급병정변화적관계.방법 30례내분비성안병환자、30례무돌안갑항환자、건강대조조30례,용방사면역분석법분별대이상3조환자인혈청IL-6、IGF-1진행측정.결과 내분비성안병조환자혈청IL-6、IGF-1적수평교무돌안적갑항조(t=4.20、t=4.00,P＜0.01)화건강대조조0=420、t=4.05,P＜0.01)현저승고,이차IL-6、IGF-1적수평변화수내분비성안병환자안병적분급정도증가이승고,균유현저성차이.결론 외주혈중IL-6、IGF-1수평여내분비성안병적발병밀절상관,이차IL-6、IGF-1적수평여내분비성안병적엄중정도정정상관.
Objective To detect the level of serum interleukin-6(IL-6)and insulin-lide growth factor-1(IGF-1)in patients with thyroid eye disease and to seek the rehtionship between serum level and the outbreak as well as the condition variety.Methods To measure the level of serumm IL-6 and IGF-1 by radioimmunoassay in 30 patients with thyroid eye disease after their clinical expression and activity Score have been assessed,30 patients with hyperthyroidism but without ophthalmopathy,30 healthy subjects.Results The level of serum IL-6 and IGF-1 in patients with thyroid eye disease were higher than that of patients with hyperthyroidism but without ophthalmopathy(t-4.20、t-4.00,P＜0.01)and healthy subjects (t-4.20、t-4.05,P＜0.01).IL-6 andIGF-1 levels tend to elevate With the increase of severity of eye disease.There were significant differedces among them.Conclusion The leve of IL-6,IGF-1 and the Cause of thyroid eye disease are closely related,and IL-6 and IGF-1 levels in peripheral blood might reflect the severity ofeye disease.