中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
20期
2755-2757
,共3页
鼻咽肿瘤%表皮生长因子受体%免疫组化
鼻嚥腫瘤%錶皮生長因子受體%免疫組化
비인종류%표피생장인자수체%면역조화
Nasopharyngeal neoplasms%Epidermal growth factor receptor%Immunohistochemistry
目的 探讨表皮生长因子受体(EGFR)在鼻咽癌(NPC)组织中的表达及临床意义.方法 应用免疫组织化学SP法检测55例NPC组织及20例鼻咽非肿瘤组织EGFR表达.结果 鼻咽癌组织EGFR阳性率96,3%(53/55)明显高于正常鼻咽黏膜组织中和10%(2/20)(x2=7.123,P＜0.01);鼻咽癌组织中EG-FR蛋白的过表达率与淋巴结转移、远处转移有相关性(x2=3.785、3.845,P＜0.05);5年总生存率(overall survival,OS)为65.5%,低表达患者5年总生存率75.35%,明显高于高表达52.4%(x2=3.925,P＜0.05);用Cox比例风险模型分析显示T分期、N分期和年龄是OS的独立预后因素(P=0.001,P=0.009,P=0.019).结论 EGFR与鼻咽癌的发生、发展有关可作为评估鼻咽癌进展和判断预后的重要指标.
目的 探討錶皮生長因子受體(EGFR)在鼻嚥癌(NPC)組織中的錶達及臨床意義.方法 應用免疫組織化學SP法檢測55例NPC組織及20例鼻嚥非腫瘤組織EGFR錶達.結果 鼻嚥癌組織EGFR暘性率96,3%(53/55)明顯高于正常鼻嚥黏膜組織中和10%(2/20)(x2=7.123,P＜0.01);鼻嚥癌組織中EG-FR蛋白的過錶達率與淋巴結轉移、遠處轉移有相關性(x2=3.785、3.845,P＜0.05);5年總生存率(overall survival,OS)為65.5%,低錶達患者5年總生存率75.35%,明顯高于高錶達52.4%(x2=3.925,P＜0.05);用Cox比例風險模型分析顯示T分期、N分期和年齡是OS的獨立預後因素(P=0.001,P=0.009,P=0.019).結論 EGFR與鼻嚥癌的髮生、髮展有關可作為評估鼻嚥癌進展和判斷預後的重要指標.
목적 탐토표피생장인자수체(EGFR)재비인암(NPC)조직중적표체급림상의의.방법 응용면역조직화학SP법검측55례NPC조직급20례비인비종류조직EGFR표체.결과 비인암조직EGFR양성솔96,3%(53/55)명현고우정상비인점막조직중화10%(2/20)(x2=7.123,P＜0.01);비인암조직중EG-FR단백적과표체솔여림파결전이、원처전이유상관성(x2=3.785、3.845,P＜0.05);5년총생존솔(overall survival,OS)위65.5%,저표체환자5년총생존솔75.35%,명현고우고표체52.4%(x2=3.925,P＜0.05);용Cox비례풍험모형분석현시T분기、N분기화년령시OS적독립예후인소(P=0.001,P=0.009,P=0.019).결론 EGFR여비인암적발생、발전유관가작위평고비인암진전화판단예후적중요지표.
Objective To investigate the expressions and clinical significance of epidermal growth factor receptor(EGFR) in patients with nasopharyngeal carcinoma(NPC). Methods 55 cases with NPC and 20 cases with noncancerous nasopharyngeal epithelial samples were retrospectively studied and the expressions of EGF and IGF-1 receptors were detected by immunohistochemical staining. Results The positive rate of EGFR 96.3% (53/55) in nasopharyngeal carcinoma was significantly higher than the 10% ( 2/20 ) in normal nasopharyngeal mucosa ( x2 =7. 123,P ＜ 0. 01 ) ;EGFR protein over-expression in nasopharyngeal carcinoma with lymph node metastasis, distant metastasis were correlated ( x2 = 3. 785, x2 = 3. 845, P ＜ 0. 05 ); The 5 -year overall survival ( OS ) in NPC was 65. 5 %,The patients with low expression of 5-year overall survival 75.35% was significantly higher than the 52.4% in high expression( x2 = 3. 925,P ＜ 0. 05 ); Using Cox proportional hazards model analysis showed that T stage, N stage and age are OS independent prognostic factor(P =0.001 ,P=0. 009,P =0.019). Conclusion EGFR had synergistic effects and may play an important role in the development and progression of NPC. The expression of EGFR could be useful biomarkes to assess clinical status and prognosis of patients with NPC.
