CAJ | 학술논문

目的探讨微波消融致离体猪肝弹性改变及其与肝组织坏死程度之间的对应关系.方法以离体猪肝为消融模型,利用弹性超声的色彩显示和应变率比值定量检测对消融前后靶区的弹性进行对照研究,同步观察靶区的组织学变化.结果随微波功率增大和消融时间加长,消融区的弹性显著降低,硬度增大,同时细胞坏死和碳化程度加重,并以微波功率的影响为著.结论弹性超声检查提示微波消融令离体猪肝迅速变硬,可从硬变程度推断凝固坏死的程度.
목적 탐토미파소융치리체저간탄성개변급기여간조직배사정도지간적대응관계.방법 이리체저간위소융모형,이용탄성초성적색채현시화응변솔비치정량검측대소융전후파구적탄성진행대조연구,동보관찰파구적조직학변화.결과 수미파공솔증대화소융시간가장,소융구적탄성현저강저,경도증대,동시세포배사화탄화정도가중,병이미파공솔적영향위저.결론 탄성초성검사제시미파소융령리체저간신속변경,가종경변정도추단응고배사적정도.
Objective To investigate the elasticity reduction of liver tissue due to microwave ablation and the relevance to the histographic damages. Methods An experimental study using fresh porcine liver was designed. Elasto-ultrasonography scanning both in color display and strain ratio calculations was conducted before and 5 min after microwave ablation ( 2450 MHz) in manner of antenna insertion under ultrasound guidance to determine the alterations of the liver elasticity, in correspondence with the histopathologic assessment of each ROI. Results Elasto-ultrasonography showed a significant elasticity reduction and hardness augment of the targeted liver tissue and the corresponding histopathology revealed increases in the amount of massive coagulative necrosis and coking of liver cells after microwave irradiation,in proportional to the applied field power and working time. Conclusions Elasto-ultrasonography helps to demonstrate microwave-induced lesion in porcine liver got rapidly hardened. It is possible to estimate the tissue necrosis to the changing of tissue hardening.