CAJ | 학술논문

目的探讨BCSG1、S100A4和VEGF在人乳腺肿瘤中的表达情况,研究其在乳腺癌发生、发展中的生物学意义并观察其与乳腺癌浸润及转移的内在关系.方法本研究通过对40例乳腺纤维腺瘤、62例乳腺浸润性导管癌组织(根据有无腋窝淋巴结转移分为1、2两组)及其癌旁组织48例,采用免疫组织化学技术SP法,对上述三指标的表达情况进行对比观察.结果 BCSG1、S100A4和VEGF在乳腺组织中的阳性表达四组比较差异均有统计学意义(P＜0.05).结论乳腺癌组织中BCSG1、S100A4和VEGF阳性表达率升高,提示乳腺肿瘤的浸润和转移能力增强;三指标的阳性表达率和肿瘤病理分级呈正相关;联合检测三种指标的表达状况将有助于乳腺癌的早期诊断和预后判断.
목적 탐토BCSG1、S100A4화VEGF재인유선종류중적표체정황,연구기재유선암발생、발전중적생물학의의병관찰기여유선암침윤급전이적내재관계.방법 본연구통과대40례유선섬유선류、62례유선침윤성도관암조직(근거유무액와림파결전이분위1、2량조)급기암방조직48례,채용면역조직화학기술SP법,대상술삼지표적표체정황진행대비관찰.결과 BCSG1、S100A4화VEGF재유선조직중적양성표체사조비교차이균유통계학의의(P＜0.05).결론 유선암조직중BCSG1、S100A4화VEGF양성표체솔승고,제시유선종류적침윤화전이능력증강;삼지표적양성표체솔화종류병리분급정정상관;연합검측삼충지표적표체상황장유조우유선암적조기진단화예후판단.
Objective To study the expression of BCSG1 ,S100A4,VEGF in human breast cancer.Methods Immunohistochemistry technique SP method was used to examine breast fibroadenoma in 40 cases,breast invasive ductal carcinoma in 62 cases ( by armpit lymph node metastasis as 2 groups) and corresponding paratumor tissues in 48 cases. Results Among the 4 groups, there was significant difference ( P＜0.05 ) in the positive immunostaining rate of BCSG1 ,S100A4, VEGF. Conclusions In the breast invasive ductal carcinoma, the expression of BCSG1, S100A4 and VEGF increased. This suggested the invasive and metastasis ability of the neoplasm enhanced. The expression were in positive correlation with tumor pathology. Combined detection of BCSG1, S100A4, VEGF expression contributes to the early diagnosis and prognostic assessment of the carcinoma of the breast.