CAJ | 학술논문

目的评价内镜下组织黏合剂注射治疗胃底静脉曲张的远期疗效及不良反应.方法回顾性分析2004年4月至2011年12月间在复旦大学附属中山医院接受内镜下组织黏合剂(α-氰丙稀酸烷基酯)注射治疗的169例胃底静脉曲张患者的临床及随访资料.结果 169例患者中男性128例,女性41例,年龄37～85(平均56.8)岁.169例患者中131例注射组织黏合剂1次,38例注射2次或2次以上,平均1.12次/例,每次注射1～3(平均1.7)ml.单纯组织黏合剂注射者83例,联合食管静脉曲张套扎治疗者231例,联合硬化剂注射者50例.所有患者术后均接受了随访,随访时间1～78(平均3.4)个月,其中显效130例(76.9％),有效36例(21.3％),无效3例(1.8％).术后出现异位栓塞2例(1.2％),再出血5例(3.0％).术后未出现败血症和食管狭窄等并发症,亦无术后2周内死亡病例.结论内镜下组织黏合剂注射治疗胃底静脉曲张简便、安全并有效.
목적 평개내경하조직점합제주사치료위저정맥곡장적원기료효급불량반응.방법 회고성분석2004년4월지2011년12월간재복단대학부속중산의원접수내경하조직점합제(α-청병희산완기지)주사치료적169례위저정맥곡장환자적림상급수방자료.결과 169례환자중남성128례,녀성41례,년령37～85(평균56.8)세.169례환자중131례주사조직점합제1차,38례주사2차혹2차이상,평균1.12차/례,매차주사1～3(평균1.7)ml.단순조직점합제주사자83례,연합식관정맥곡장투찰치료자231례,연합경화제주사자50례.소유환자술후균접수료수방,수방시간1～78(평균3.4)개월,기중현효130례(76.9％),유효36례(21.3％),무효3례(1.8％).술후출현이위전새2례(1.2％),재출혈5례(3.0％).술후미출현패혈증화식관협착등병발증,역무술후2주내사망병례.결론 내경하조직점합제주사치료위저정맥곡장간편、안전병유효.
Objective To evaluate the long-term efficacy and safety of endoscopic tissue adhesive (N-oclyl-α-cyanoacylate) injection for the treatment of gastric varices. Methods A retrospective study was performed to review the clinical and follow up data of 169 patients with gastric variceal who received tissue adhesive injection at the Fudan University Affiliated Zhongshan Hospital between April 2004 and December 2011.Results There were 128 males and 41 females with a mean age of 56.8 (37-85) years old.One hundred and thirty-one patients received one injection,38 received two injections or more with a mean of 1.12 per patient.Volume of injection ranged from 1 to 3 ml (mean, 1.7 ml). Eighty-three patients received adhesive injection alone, 231 received injection combined with ligation,50 received combined sclerotic agent injection.All the patients had follow up ranging from 1 to 78 months (mean,3.4 months).The treatment outcome was satisfactory in 130patients(76.9％),good in 36(21.3％),and ineffective in 3 (1.8％).The rate of ectopic embolization was 3.0％,and the rate of early re-bleeding was 1.2％.Postoperatively there were no septic complications or esophageal stricture.There were no deaths within 2 weeks.Conclusion Injection of tissue adhesive under endoscopic guidance for treatment of gastric varices is convenient,safe and effective.