CAJ | 학술논문

髓系来源抑制细胞(MDSC)是髓系来源的一群异质细胞,在荷瘤小鼠模型及肿瘤患者均发挥免疫抑制作用.肿瘤MDSC免疫逃逸作用的机制目前已取得了很多进展,这群细胞可以通过上调精氨酸酶1(ARN1),诱导一氧化氮合酶(iNOS or NOS-2)表达,增加一氧化氮(NO)、活化氧自由基(ROS)等的释放,分解肿瘤微环境中的半胱氨酸、下调T细胞表面L选择素水平并抑制T细胞功能,MDSC还可诱导体内调节性T细胞(Tr)形成、调节固有免疫.此外,MDSC可通过分化为肿瘤相关巨噬细胞(TAM)、分泌Th-2型细胞因子、促进肿瘤血管生成及肿瘤转移等一系列机制促进肿瘤细胞逃避免疫监视.
수계래원억제세포(MDSC)시수계래원적일군이질세포,재하류소서모형급종류환자균발휘면역억제작용.종류MDSC면역도일작용적궤제목전이취득료흔다진전,저군세포가이통과상조정안산매1(ARN1),유도일양화담합매(iNOS or NOS-2)표체,증가일양화담(NO)、활화양자유기(ROS)등적석방,분해종류미배경중적반광안산、하조T세포표면L선택소수평병억제T세포공능,MDSC환가유도체내조절성T세포(Tr)형성、조절고유면역.차외,MDSC가통과분화위종류상관거서세포(TAM)、분비Th-2형세포인자、촉진종류혈관생성급종류전이등일계렬궤제촉진종류세포도피면역감시.
Myeloid derived suppressor cells (MDSC) are a group of heterogeneous myeloid cells,which play a role in immune suppression in tumour-bearing mice and cancer patients. MDSC may suppress T cells by upregulating the expression or release of arginase1 ( ARN1 ), inducible nitric oxide synthase ( iNOS or NOS-2), nitric oxide ( NO), reactive oxygen species ( ROS), and disintegrating cysteine in tunour microenvironment, downregulating L-selectin of T cell. In addition, MDSC could enhance immune escape by inducing T regulatory cells, modulating innate immune, differentiating to tumor associated macrophage (TAM), secreting Th-2 type cytokines, or promoting vascular formation of tumor.