CAJ | 학술논문

随着器官和组织移植技术的进步，胰腺和胰岛移植已开始用于治疗糖尿病并成为热点，但是关于胰岛细胞的来源问题还是存在着许多不足和改进之处。其中骨髓间充质干细胞(BMSCs)因为具有获取简单、易于培养和免疫抑制等优点成为被诱导为胰岛样细胞的热点。近几年来人工构建类胰岛细胞（即利用基因重组及基因转染再造胰岛样细胞）的技术提高了单纯使用诱导剂后的细胞诱导率和胰岛素分泌量,为糖尿病的治疗提供了新的思路与方向。
수착기관화조직이식기술적진보，이선화이도이식이개시용우치료당뇨병병성위열점，단시관우이도세포적래원문제환시존재착허다불족화개진지처。기중골수간충질간세포(BMSCs)인위구유획취간단、역우배양화면역억제등우점성위피유도위이도양세포적열점。근궤년래인공구건류이도세포（즉이용기인중조급기인전염재조이도양세포）적기술제고료단순사용유도제후적세포유도솔화이도소분비량,위당뇨병적치료제공료신적사로여방향。
As the progress of organ and tissue transplantation technology, pancreas and islet transplantation has been introduced to treat diabetes and became hot. However, many shortcomings and re-lated issues need to be improved concerning the islet cell sources. Bone marrow mesenchymal stem cells (BMSCs) has become the hot topic on induction of islet-like cell because it was simple to access, easy to culture and possess the function of immunosuppressian. In recent years, artificial construction of pancreatic islet cells, which uses gene recombinant and gene transfection to reforge islet-like cells, has improved the induction rate of BMSCs and increased the amount of insulin serection, and it also provide new ideas and direction for the treatment of diabetes.