CAJ | 학술논문

癌性恶病质传统的治疗方法一般在晚期进行干预,以增加营养摄人为主,并且多以体重做为判断疗效的标准,大量临床试验证明效果并不理想.最近的研究表明在恶病质早期即以蛋白酶体为靶点进行靶向治疗,并与传统治疗相结合,治疗后核因子-KB(NF-KB)水平降低,肌纤维蛋白破坏终止,血浆蛋白及瘦体数量升高,功能好转.
암성악병질전통적치료방법일반재만기진행간예,이증가영양섭인위주,병차다이체중주위판단료효적표준,대량림상시험증명효과병불이상.최근적연구표명재악병질조기즉이단백매체위파점진행파향치료,병여전통치료상결합,치료후핵인자-KB(NF-KB)수평강저,기섬유단백파배종지,혈장단백급수체수량승고,공능호전.
Cancer cachexia(CC)caused by cancer is a syndrome with complicated symptoms.Traditional therapies usually give interventions for more nutrition intake at CC late stage and take weight as the outcome marker.Lots of clinical trials demonstrate that the effect is not satisfactory.Recent studies show that the level of NF-KB decreased,termination of the breakdown of myofibrillar proteins,the serum proteins and lean body mass increased and function improvement after targeting proteasome at early stage of CC combined with traditional therapy.