国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
2期
107-112
,共6页
细胞间黏附分子-1%细胞黏附%炎症
細胞間黏附分子-1%細胞黏附%炎癥
세포간점부분자-1%세포점부%염증
ICAM-1%Cell adhesion%Inflammation
细胞间黏附分子-1( ICAM-1)是一种细胞表面的跨膜糖蛋白,可介导细胞与细胞间或细胞与细胞外基质之间的相互作用.ICAM-1广泛地参与细胞黏附、炎症的发生发展、信号转导和肿瘤转移等多种重要的生理及病理过程.在临床上,ICAM-1可作为多种炎症或肿瘤发展和预后的重要生物标记物之一.以ICAM-1为靶点的药物或能预防和治疗多种急、慢性炎症引起的组织损伤和肿瘤等.
細胞間黏附分子-1( ICAM-1)是一種細胞錶麵的跨膜糖蛋白,可介導細胞與細胞間或細胞與細胞外基質之間的相互作用.ICAM-1廣汎地參與細胞黏附、炎癥的髮生髮展、信號轉導和腫瘤轉移等多種重要的生理及病理過程.在臨床上,ICAM-1可作為多種炎癥或腫瘤髮展和預後的重要生物標記物之一.以ICAM-1為靶點的藥物或能預防和治療多種急、慢性炎癥引起的組織損傷和腫瘤等.
세포간점부분자-1( ICAM-1)시일충세포표면적과막당단백,가개도세포여세포간혹세포여세포외기질지간적상호작용.ICAM-1엄범지삼여세포점부、염증적발생발전、신호전도화종류전이등다충중요적생리급병리과정.재림상상,ICAM-1가작위다충염증혹종류발전화예후적중요생물표기물지일.이ICAM-1위파점적약물혹능예방화치료다충급、만성염증인기적조직손상화종류등.
Intercellular adhesion molecule-1 ( ICAM-1 ) is a surface glycosylated transmembrane protein that mediates the adhesion between cells and between cell and extracellular matrix.ICAM-1 is widely involved in the regulation of multitude cellular functions,such as cell adhesion,inflammation,signal transduction and tumor metastasis.Clinically,ICAM-1 can be considered to be one of the key biomarkers for many kinds of inflammation and tumor relapse and prognosis.The drugs and medications that target ICAM-1 might be used to prevent and treat tumors and tissue damages cansed by various acute and chronic inflammation.
