CAJ | 학술논문

抗菌肽(antimicrobal peptides,AMPs)是天然免疫系统中的一种小分子多肽,一些具有抗肿瘤活性,毒副反应小,不易产生耐药性.近年来,研究已经明确了抗菌肽对肿瘤细胞的杀伤抑制作用及其作用机制,其中作用机制包括以下5方面:(1)在肿瘤细胞膜上形成穿膜孔道,使肿瘤细胞死亡;(2)作用于细胞骨架使其结构紊乱;(3)抑制DNA合成,影响细胞增殖;(4)作用于线粒体,引起肿瘤细胞凋亡;(5)影响免疫效应进而杀伤肿瘤细胞.该文就抗菌肽抗肿瘤细胞的作用机制作一综述.
항균태(antimicrobal peptides,AMPs)시천연면역계통중적일충소분자다태,일사구유항종류활성,독부반응소,불역산생내약성.근년래,연구이경명학료항균태대종류세포적살상억제작용급기작용궤제,기중작용궤제포괄이하5방면:(1)재종류세포막상형성천막공도,사종류세포사망;(2)작용우세포골가사기결구문란;(3)억제DNA합성,영향세포증식;(4)작용우선립체,인기종류세포조망;(5)영향면역효응진이살상종류세포.해문취항균태항종류세포적작용궤제작일종술.
Antimicrobial peptides(AMPs) are a class of small peptides widely existing in many organ isms,some are with broad spectrum of antitumor activities and uneasily to develop drug resistance. In the last decade intensive research has been conducted to determine the role of innate immunity antimicrobial peptides in the killing effect on cancer cells and the antitumor mechanism of antimicrobial peptides. The general antitumor mechanism of antimicrobial peptides is recognized as following: (1)to kill the tumor cells by forming pore on the membrane and leading depolarization of cell membrane,(2) to disturb the cytoskeletal structure,(3) to inhibit the DNA synthesis,interfere with cell proliferation,(4)to act on mitochondria to induce apoptosis of tumor cells,(5) to kill the tumor cells by affecting the immune response. This paper reviewed the molecular mechanism of killing effect of antimicrobial peptides on tumor cells.