国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2010年
21期
1321-1323
,共3页
贾永良%谢强敏%张洪泉%张琳惠
賈永良%謝彊敏%張洪泉%張琳惠
가영량%사강민%장홍천%장림혜
慢性阻塞性肺疾病%吸烟%发病机制
慢性阻塞性肺疾病%吸煙%髮病機製
만성조새성폐질병%흡연%발병궤제
Chronic obstructive pulmonary disease%Smoking%Pathogenesis
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的发病率近年来呈现上升趋势,目前已占到了疾病死亡原因的第4位,预计到2020年将上升到第3位.COPD是一个重要的公众健康问题,它是世界范围内引起高发病率和死亡率的一个重要原因.在我国,40岁以上人群COPD的总患病率达8.2%,呼吸系统疾病(其中COPD占很大部分)在农村处于第3位死因、在城市处于第4位死因,每年有一百万人死亡和五百万人致残.因此,对COPD发病机制的研究显的尤为重要,COPD是一种多因素引起的疾病,既有自身的因素,也有环境因素.在环境因素中,吸烟、空气污染及感染是导致COPD发病的三大危险因素,而其中吸烟是最主要的因素.近年来,吸烟对COPD的影响的研究取得了较大的进展,现综述了近几年吸烟对COPD发病机制的影响,同时希望对COPD发病机制的深入研究有一定的意义.
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的髮病率近年來呈現上升趨勢,目前已佔到瞭疾病死亡原因的第4位,預計到2020年將上升到第3位.COPD是一箇重要的公衆健康問題,它是世界範圍內引起高髮病率和死亡率的一箇重要原因.在我國,40歲以上人群COPD的總患病率達8.2%,呼吸繫統疾病(其中COPD佔很大部分)在農村處于第3位死因、在城市處于第4位死因,每年有一百萬人死亡和五百萬人緻殘.因此,對COPD髮病機製的研究顯的尤為重要,COPD是一種多因素引起的疾病,既有自身的因素,也有環境因素.在環境因素中,吸煙、空氣汙染及感染是導緻COPD髮病的三大危險因素,而其中吸煙是最主要的因素.近年來,吸煙對COPD的影響的研究取得瞭較大的進展,現綜述瞭近幾年吸煙對COPD髮病機製的影響,同時希望對COPD髮病機製的深入研究有一定的意義.
만성조새성폐질병(chronic obstructive pulmonary disease,COPD)적발병솔근년래정현상승추세,목전이점도료질병사망원인적제4위,예계도2020년장상승도제3위.COPD시일개중요적공음건강문제,타시세계범위내인기고발병솔화사망솔적일개중요원인.재아국,40세이상인군COPD적총환병솔체8.2%,호흡계통질병(기중COPD점흔대부분)재농촌처우제3위사인、재성시처우제4위사인,매년유일백만인사망화오백만인치잔.인차,대COPD발병궤제적연구현적우위중요,COPD시일충다인소인기적질병,기유자신적인소,야유배경인소.재배경인소중,흡연、공기오염급감염시도치COPD발병적삼대위험인소,이기중흡연시최주요적인소.근년래,흡연대COPD적영향적연구취득료교대적진전,현종술료근궤년흡연대COPD발병궤제적영향,동시희망대COPD발병궤제적심입연구유일정적의의.
The morbidity of chronic obstructive pulmonary disease (COPD) is rising recently,which has become the fourth leading cause of death at present and the number is expected to climb to the third by the year 2020. COPD is an important public health problem, a significant cause leading to high morbidity and mortality worldwide. In China, the total prevalence rate of COPD above 40-year-old crowd was 8. 2%. Respiratory system diseases (COPD account for a large proportion of the total) are the third leading cause of death in rural areas while the fourth in large urban areas,resulting in one million deaths and five million disabilities a year. Therefore,it seems to be great significant to study the pathogenesis of COPD. COPD is a disease involving multiple factors, which include self element as well as environmental factors. Smoking, air pollution and infection are the three hazards bringing about COPD during environmental factors, especially smoking is the leading element. Studies of the smoking's effects on COPD have progressed greatly in recent years. This article summarizes research into the influence of smoking on the pathogenesis of COPD these years and hopes it will be of certain significance to the further research of the pathogenesis of COPD.