中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2011年
z1期
61-64
,共4页
梅国城%彭骊苏%刘静%周红梅%郭素华%林梅
梅國城%彭驪囌%劉靜%週紅梅%郭素華%林梅
매국성%팽려소%류정%주홍매%곽소화%림매
扁平苔藓,口腔%免疫%中医辨证
扁平苔蘚,口腔%免疫%中醫辨證
편평태선,구강%면역%중의변증
Lichen planus,oral%Immunity%Traditional Chinese medical differentiation
目的 通过观察不同证型口腔扁平苔藓( lichen planus,OLP)患者的全身免疫状况,探讨中医证型与免疫的关系,以期为临床判断OLP患者免疫状况提供一种新思路.方法 纳入70例OLP患者,分为心脾蕴热型、肝经实火型、虚火上炎型和气血两虚型,所有患者均行免疫检查并对结果进行统计学分析.结果 在OLP患者中虚火上炎型37例,所占的比例最大[53％ (37/70)]；OLP患者的外周血细胞总体表现为CD-3、CD-4与正常参考值相比均显著降低(P＜0.05),降低比例分别为76％ (53/70)和63％( 44/70)；与正常参考值相比,心脾蕴热型组CD-3 (55.44±5.57)、CD-8(15.60±3.93)均显著降低(P＜0.05),CD-4/CD-8( 2.40±0.69)显著升高(P＜0.05),IgM(2279.33±729.23)显著升高(P＜0.05)；虚火上炎型组CD-4( 30.52±7.50)显著降低(P＜0.05),IgA(2608.70±728.59)显著升高(P＜0.05)；气血两虚型组CD-3( 56.10±3.24)显著降低(P＜0.05).结论 OLP患者的全身免疫状态以细胞免疫紊乱为主；不同中医证型的OLP患者其免疫状况存在一定差异性.
目的 通過觀察不同證型口腔扁平苔蘚( lichen planus,OLP)患者的全身免疫狀況,探討中醫證型與免疫的關繫,以期為臨床判斷OLP患者免疫狀況提供一種新思路.方法 納入70例OLP患者,分為心脾蘊熱型、肝經實火型、虛火上炎型和氣血兩虛型,所有患者均行免疫檢查併對結果進行統計學分析.結果 在OLP患者中虛火上炎型37例,所佔的比例最大[53％ (37/70)]；OLP患者的外週血細胞總體錶現為CD-3、CD-4與正常參攷值相比均顯著降低(P＜0.05),降低比例分彆為76％ (53/70)和63％( 44/70)；與正常參攷值相比,心脾蘊熱型組CD-3 (55.44±5.57)、CD-8(15.60±3.93)均顯著降低(P＜0.05),CD-4/CD-8( 2.40±0.69)顯著升高(P＜0.05),IgM(2279.33±729.23)顯著升高(P＜0.05)；虛火上炎型組CD-4( 30.52±7.50)顯著降低(P＜0.05),IgA(2608.70±728.59)顯著升高(P＜0.05)；氣血兩虛型組CD-3( 56.10±3.24)顯著降低(P＜0.05).結論 OLP患者的全身免疫狀態以細胞免疫紊亂為主；不同中醫證型的OLP患者其免疫狀況存在一定差異性.
목적 통과관찰불동증형구강편평태선( lichen planus,OLP)환자적전신면역상황,탐토중의증형여면역적관계,이기위림상판단OLP환자면역상황제공일충신사로.방법 납입70례OLP환자,분위심비온열형、간경실화형、허화상염형화기혈량허형,소유환자균행면역검사병대결과진행통계학분석.결과 재OLP환자중허화상염형37례,소점적비례최대[53％ (37/70)]；OLP환자적외주혈세포총체표현위CD-3、CD-4여정상삼고치상비균현저강저(P＜0.05),강저비례분별위76％ (53/70)화63％( 44/70)；여정상삼고치상비,심비온열형조CD-3 (55.44±5.57)、CD-8(15.60±3.93)균현저강저(P＜0.05),CD-4/CD-8( 2.40±0.69)현저승고(P＜0.05),IgM(2279.33±729.23)현저승고(P＜0.05)；허화상염형조CD-4( 30.52±7.50)현저강저(P＜0.05),IgA(2608.70±728.59)현저승고(P＜0.05)；기혈량허형조CD-3( 56.10±3.24)현저강저(P＜0.05).결론 OLP환자적전신면역상태이세포면역문란위주；불동중의증형적OLP환자기면역상황존재일정차이성.
Objective To investigate the relationship between traditional Chinese medical differentiation and immunity by observing the immunity of different types of lichen planus(OLP) patients and to proffer a new way of thinking on how to clinically identify the immune state of the patients.Methods Seventy cases of OLP patients were included,who were grouped into the type of accumulated heat of both heart and spleen,the type of hyperactivity of liver-fire,the type of flaring up of deficient fire and the type of deficiency of both qi and blood respectively.All patients received immune-examination,and the data were statistically analyzed.Results In OLP patients the type of flaring up of deficient fire accounted for the majority[53％ (37/70) ].The peripheral blood cells of the OLP patients generally expressed less CD-3 and CD-4 than normal[76％ (53/70) and 63％ (44/70) of the normal respectively,P ＜ 0.05 ].CD-3 (55.44 ± 5.57 ) and CD-8 ( 15.60 ± 3.93 ) were remarkably lower in the group of accumulated heat of both heart and spleen whereas CD-4/CD-8 (2.40 ± 0.69) and IgM (2279.33 ±729.23) went up.CD-4(30.52 ±7.50) in the group of flaring up of deficient fire decreased notably,and IgA (2608.7 ± 728.59) went up ( P ＜ 0.05).CD-3 (56.10 ± 3.24 ) in the group of deficiency of qi and blood went down remarkably.Conclusions The overall immune state of the OLP patients shows that the cell immunity is primarily out of order.The immune states of the OLP patients in different traditional Chinese medical types remain to a certain extent different.
