中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
6期
33-35
,共3页
陈昱明%黄军荣%张纯%成奇峰%张志娟%孙彦秋
陳昱明%黃軍榮%張純%成奇峰%張誌娟%孫彥鞦
진욱명%황군영%장순%성기봉%장지연%손언추
复发性鼻咽肿瘤%放射治疗%逐步递量加速超分割放射治疗
複髮性鼻嚥腫瘤%放射治療%逐步遞量加速超分割放射治療
복발성비인종류%방사치료%축보체량가속초분할방사치료
Recurrent nasopharyngeal carcinoma%Radiotherapy%Escalated hyperfractionated accelerated radiation therapy
目的 观察逐步递量加速超分割放射治疗复发性鼻咽癌的近期疗效及毒副反应.方法 46例复发性鼻咽癌随机分为常规分割放疗组(对照组)及逐步递量加速超分割放疗组(研究组),每组各23例.对照组:常规照射.2 Gy/次,1次/d,5.次/周,鼻咽部复发灶总荆量DT 60～66 Gy/6.0～6.6用;研究组:第1、2、3、4、5周剂量分别为1.1、1.2、1.3、1.4、1.5 Gy/次,每天2次,两次间隔时间＞6 h,每周5次,鼻咽部复发灶总剂量DT 65 Gy/5周.结果 放疗结束后3个月,研究组和对照组鼻咽复发灶完全缓解(CR)、部分缓解(PR)率分别为82.6%、17.4%和52.2%、47.8%(P＜0.05),两组比较差异有统计学意义.研究组口咽急性放射性反应高于对照组(P＜0.05),但是可以耐受.结论 逐步递量加速超分割放疗能提高复发性鼻咽癌的近期疗效,急性放射性反应患者可以耐受,远期疗效和后期放射损伤有待进一步随诊观察.
目的 觀察逐步遞量加速超分割放射治療複髮性鼻嚥癌的近期療效及毒副反應.方法 46例複髮性鼻嚥癌隨機分為常規分割放療組(對照組)及逐步遞量加速超分割放療組(研究組),每組各23例.對照組:常規照射.2 Gy/次,1次/d,5.次/週,鼻嚥部複髮竈總荊量DT 60～66 Gy/6.0～6.6用;研究組:第1、2、3、4、5週劑量分彆為1.1、1.2、1.3、1.4、1.5 Gy/次,每天2次,兩次間隔時間＞6 h,每週5次,鼻嚥部複髮竈總劑量DT 65 Gy/5週.結果 放療結束後3箇月,研究組和對照組鼻嚥複髮竈完全緩解(CR)、部分緩解(PR)率分彆為82.6%、17.4%和52.2%、47.8%(P＜0.05),兩組比較差異有統計學意義.研究組口嚥急性放射性反應高于對照組(P＜0.05),但是可以耐受.結論 逐步遞量加速超分割放療能提高複髮性鼻嚥癌的近期療效,急性放射性反應患者可以耐受,遠期療效和後期放射損傷有待進一步隨診觀察.
목적 관찰축보체량가속초분할방사치료복발성비인암적근기료효급독부반응.방법 46례복발성비인암수궤분위상규분할방료조(대조조)급축보체량가속초분할방료조(연구조),매조각23례.대조조:상규조사.2 Gy/차,1차/d,5.차/주,비인부복발조총형량DT 60～66 Gy/6.0～6.6용;연구조:제1、2、3、4、5주제량분별위1.1、1.2、1.3、1.4、1.5 Gy/차,매천2차,량차간격시간＞6 h,매주5차,비인부복발조총제량DT 65 Gy/5주.결과 방료결속후3개월,연구조화대조조비인복발조완전완해(CR)、부분완해(PR)솔분별위82.6%、17.4%화52.2%、47.8%(P＜0.05),량조비교차이유통계학의의.연구조구인급성방사성반응고우대조조(P＜0.05),단시가이내수.결론 축보체량가속초분할방료능제고복발성비인암적근기료효,급성방사성반응환자가이내수,원기료효화후기방사손상유대진일보수진관찰.
Objective To observe the immediate responses and side effects in escalated hyperfractionated accelerated radiation therapy for recurrent nasopharyngeal carcinoma(NPC).Methods A total of 46 patients with recurrent nasopharyngeal carcinoma were randomized into two groups,the conventional fractionation group(control group)and the escalated hyperfractionated accelerated radiation therapy group(study group).Twenty-three patients were asigned to each group.The control group patients were treated by 2 Gy daily,5 days per week,the total dose of nasopharyngeal carcinoma was 60-66 Gy.The study group patients were treated by escalated dose:1.1,1.2,1.3,1.4,1.5 Gy,twice fractions daily(over 6 hours interval)were given from the 1st to 5th weeks respectively,The total dose of nasopharyngeal carcinoma was 65 Gy.Results Three months after finishing the radiotherapy,the CR and PR rates of recurrent lesions were 82.6%,17.4% in the study group and 52.2%,47.8% in the control group(P＜0.05).There was significant difference between the two groups.The acute radiation reaction of pharynx was higher in the study group than that in the control group,There was significant difference between the two groups(P＜0.05).Conclusions The results of this study showed that escalated hyperfractionated accelerated radiation therapy can promote immediate response for recurrent nasopharyngeal carcinoma.The survival rate and late complications in long term are worth while of further study.
