CAJ | 학술논문

目的调查研究鼻咽癌( NPC)无瘤生存者的生存质量(QOL),探索影响患者QOL的因素.方法收集中山大学肿瘤防治中心230例NPC无瘤生存者的QOL-NPC量表和人口学及临床资料(性别、年龄、教育水平、婚姻状况、人均收入、方言、其他慢性病、临床分期、治疗方法、放疗疗程、放疗阶段),使用t检验或方差分析比较不同基本资料患者的QOL,使用多因素方差分析筛选出影响患者各个维度QOL的因素.结果影响心理精神QOL的因素有放疗阶段、放疗疗程、其他慢性病,放疗后＞5年、1个疗程、无其他慢性病患者有较高的心理精神评分(均P＜ 0.05).影响社会关系QOL的因素有放疗阶段和治疗方法,放疗后＞5年、单纯放疗患者有较高的社会关系评分(均P＜ 0.05).影响副作用QOL的因素有放疗阶段,放疗后＞5年的患者有较低的毒副作用评分(P＜0.05).结论应该关注接受放射治疗、放化疗、多个疗程、有其他慢性病的NPC患者,采取针对性的预防干预措施,降低放疗对患者的损伤,减少放疗的毒副作用,提高患者的QOL.
목적 조사연구비인암( NPC)무류생존자적생존질량(QOL),탐색영향환자QOL적인소.방법 수집중산대학종류방치중심230례NPC무류생존자적QOL-NPC량표화인구학급림상자료(성별、년령、교육수평、혼인상황、인균수입、방언、기타만성병、림상분기、치료방법、방료료정、방료계단),사용t검험혹방차분석비교불동기본자료환자적QOL,사용다인소방차분석사선출영향환자각개유도QOL적인소.결과 영향심리정신QOL적인소유방료계단、방료료정、기타만성병,방료후＞5년、1개료정、무기타만성병환자유교고적심리정신평분(균P＜ 0.05).영향사회관계QOL적인소유방료계단화치료방법,방료후＞5년、단순방료환자유교고적사회관계평분(균P＜ 0.05).영향부작용QOL적인소유방료계단,방료후＞5년적환자유교저적독부작용평분(P＜0.05).결론 응해관주접수방사치료、방화료、다개료정、유기타만성병적NPC환자,채취침대성적예방간예조시,강저방료대환자적손상,감소방료적독부작용,제고환자적QOL.
Objective To evaluate the quality of life (QOL) of nasopharyngeal carcinoma (NPC) tumorfree survivors,and analyze the factors affecting the QOL of NPC patients.Methods The QOL and demographic variables (gender,age,education,marital status,income,dialects,concomitant chronic disease,clinical stage,treatment method,radiation course,and radiotherapy stages) were collected.ANOVA and t test were used to compare the QOL of NPC patients among different demographic variables. Multivariate ANOVA was used to select the influencing factors. Results The influencing factors of psychological QOL included radiotherapy stage, radiation course and concomitant chronic disease. NPC patients had higher psychological domain QOL whose survival greater than five years, had a completed course of radiation, and without other diseases (P ＜0.05).The influencing factors of social QOL included radiotherapy stage and treatment method (P＜ 0.05). The influencing factors of side-effect QOL included radiotherapy stage(P ＜ 0.05).Conclusion The NPC tumor-free survivors who survival longer, have more course of radiation and with chronic diseases should be pay more attention.Prevention interventions should be preformed to reduce radiation injury to patients; side effects,and improve QOL of NPC tumor-free patients.