肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
8期
447-449
,共3页
肠肿瘤%受体,白细胞介素2%细胞黏附分子
腸腫瘤%受體,白細胞介素2%細胞黏附分子
장종류%수체,백세포개소2%세포점부분자
Intestinal neoplasms%Receptors,interleukin-2%Cell adhesion molecules
目的 研究大肠癌血清和组织中sIL-2R和sEAM-1水平变化及意义.方法 采用双抗体夹心ELISA法对44例大肠癌手术前后、28例大肠息肉、30例对照组血清slL-2R和slCAM-1水平进行检测,并检测大肠癌及大肠息肉组织中两者水平.结果 大肠癌组血清sIL-2R、sICAM-1水平分别为(209.27±127.42)pmol/L、(693.22±276.25)ng/ml,明显高于大肠息肉组和对照组.大肠癌组织中两者水平分别为(233.66±170.22)pmol/L、(706.92±286.09)ng/ml,明显高于大肠息肉组.大肠癌血清和组织中两者水平与Duke分期有关,与组织分化程度无关.大肠癌根治性手术后1个月血清两者水平明显下降,而姑息性手术下降不明显.结论 血清和肿瘤组织中sIL-2R、sICAM-1水平变化町作为大肠癌诊断、手术方法选择、预后监测有意义的参考指标.
目的 研究大腸癌血清和組織中sIL-2R和sEAM-1水平變化及意義.方法 採用雙抗體夾心ELISA法對44例大腸癌手術前後、28例大腸息肉、30例對照組血清slL-2R和slCAM-1水平進行檢測,併檢測大腸癌及大腸息肉組織中兩者水平.結果 大腸癌組血清sIL-2R、sICAM-1水平分彆為(209.27±127.42)pmol/L、(693.22±276.25)ng/ml,明顯高于大腸息肉組和對照組.大腸癌組織中兩者水平分彆為(233.66±170.22)pmol/L、(706.92±286.09)ng/ml,明顯高于大腸息肉組.大腸癌血清和組織中兩者水平與Duke分期有關,與組織分化程度無關.大腸癌根治性手術後1箇月血清兩者水平明顯下降,而姑息性手術下降不明顯.結論 血清和腫瘤組織中sIL-2R、sICAM-1水平變化町作為大腸癌診斷、手術方法選擇、預後鑑測有意義的參攷指標.
목적 연구대장암혈청화조직중sIL-2R화sEAM-1수평변화급의의.방법 채용쌍항체협심ELISA법대44례대장암수술전후、28례대장식육、30례대조조혈청slL-2R화slCAM-1수평진행검측,병검측대장암급대장식육조직중량자수평.결과 대장암조혈청sIL-2R、sICAM-1수평분별위(209.27±127.42)pmol/L、(693.22±276.25)ng/ml,명현고우대장식육조화대조조.대장암조직중량자수평분별위(233.66±170.22)pmol/L、(706.92±286.09)ng/ml,명현고우대장식육조.대장암혈청화조직중량자수평여Duke분기유관,여조직분화정도무관.대장암근치성수술후1개월혈청량자수평명현하강,이고식성수술하강불명현.결론 혈청화종류조직중sIL-2R、sICAM-1수평변화정작위대장암진단、수술방법선택、예후감측유의의적삼고지표.
Objective To study the changes of serum and tissue soluble interleukin-2 receptor (slL-2R) and soluble intercellular adhesion moleculer-1 (sICAM-1) in eolorectal cancer and their clinical significance. Methods Serum levels of sIL-2R and sICAM-1 were detected by the double antibody sandwich ELISA method in 44 colorectal cancer patients before and after operation, 28 polyp intestinal and 30 controls. Simultaneously, tissue levels of them were measured in co]oreetal cancer and polyp intestinal. Results The serum sIL-2R[(209.27±127.42) pmol/L] and sICAM-1[(693.22±276.25) ng/ml] in coiorectal cancer were significantly higher than those in the polyp intestinal and controls.The tissue sIL-2R [(233.66±170.22)pmol/L] and sICAM-l[(706.92±286.09) ng/ml] in colorectal cancer were significantly higher than those in the polyp intestinal. The serum and tissue levels of sIL-2R and sICAM-1 in colorectal cancer had relationships with Duke stages and no relationships with the histological differentiation. The levels of serum sIL-2R and sICAM-1 declined remarkably after one month of radical operation, but it decreased illegibly after palliative operation. Conclusion Alterations of serum and tissue sIL-2R and sICAM-1 levels may be used as indicators of diagnosis, choice of operative method, judgement of prognosis in eoloreetal cancer.
