CAJ | 학술논문

目的研究乳腺导管内癌伴微浸润(ductal carcinoma in situ with microinvasion,DCIS-MI)患者的病理与临床特征.方法对本院2002年1月至2007年1月收治的43例Ⅰ、Ⅱ型DCIS-M1患者的临床资料进行回顾性对比研究.利用免疫组织化学方法进行ER-β及Her-2染色.结果 ①ER-β、Her-2阳性率分别为69.76%、25.57%;②病理分型DCIS-MI Ⅰ与DCIS-MIⅡ组,ER-p与Her-2表达具有统计学差异;肿瘤大小与ER-β、Her-2表达呈正相关;淋巴结转移数量增多,Her-2表达增高.Her-2过表达与乳腺癌临床TNM分期显著相关(P<0.001).结论乳腺癌ER-β、Her-2表达与病理类型、肿瘤大小、淋巴结转移数目及临床分期密切相关.ER-β阳性可认为是乳腺癌预后良好的指标,而Her-2的过表达则提示预后不良.
목적 연구유선도관내암반미침윤(ductal carcinoma in situ with microinvasion,DCIS-MI)환자적병리여림상특정.방법 대본원2002년1월지2007년1월수치적43례Ⅰ、Ⅱ형DCIS-M1환자적림상자료진행회고성대비연구.이용면역조직화학방법 진행ER-β급Her-2염색.결과 ①ER-β、Her-2양성솔분별위69.76%、25.57%;②병리분형DCIS-MI Ⅰ여DCIS-MIⅡ조,ER-p여Her-2표체구유통계학차이;종류대소여ER-β、Her-2표체정정상관;림파결전이수량증다,Her-2표체증고.Her-2과표체여유선암림상TNM분기현저상관(P<0.001).결론 유선암ER-β、Her-2표체여병리류형、종류대소、림파결전이수목급림상분기밀절상관.ER-β양성가인위시유선암예후량호적지표,이Her-2적과표체칙제시예후불량.
Objective To study the clinical and pathological characteristics of breast ductal carcinoma in situ with microinvasion(DCIS-MI).MethodsFrom January 2002 to January 2007,a total of 43 patients with DCIS-MI patients were retrospectively studied by calculating the protein expression of ER-a and Her-2.Results The positive expression of ER-βand Her-2 were 69.76%and 25.57%respectively.Pathology varied between DCIS-MI type I and type Ⅱ.The size of tumor was positive associated with ER-βand Her-2.It showed that the Her-2 expression was up-regulated with a increased size of tumor and number of lymplhonode in metastasis cases.Conclusion ER-βand Her-2 are associated with pathoiogi cal type,tumor size,number of lymphonode and clinical stage in breast cancer tissue.ER-βositive can be considered as a good indicator of prognosis but Her-2 is opposite.