CAJ | 학술논문

肝细胞癌简称肝癌(hepatocellular carcinoma)的发病率、病死率呈逐年上升趋势,尽管几种主要危险致病因素已经比较明确,但是肝癌发生的确切的分子生物学机制尚不完全清楚.近年来越来越多的证据表明,表观遗传修饰(epigenetics)在肝癌的发生发展中具有非常重要的作用.本文将就DNA的异常甲基化、组蛋白异常修饰与肝癌的关系,肝癌的表观遗传学检测及表观遗传学治疗现状做一综述.
간세포암간칭간암(hepatocellular carcinoma)적발병솔、병사솔정축년상승추세,진관궤충주요위험치병인소이경비교명학,단시간암발생적학절적분자생물학궤제상불완전청초.근년래월래월다적증거표명,표관유전수식(epigenetics)재간암적발생발전중구유비상중요적작용.본문장취DNA적이상갑기화、조단백이상수식여간암적관계,간암적표관유전학검측급표관유전학치료현상주일종술.
The incidence and mortality of hepatocellular carcinoma have increased in recent decades. Although the major etiological factors have been identified, the exact molecular biology mechanism remains unclear. Re- cently, more and more evidences prove that epigenetics mechanism plays an important role in hepatoceUular carcino-ma. Here we try to make a progress on the abnormal epigenetics changes, epigenetics detection and treatments of hepatocellualr carcinoma.