CAJ | 학술논문

内源性硫化氢是第3个被发现的气体信使分子.在心血管系统,硫化氢主要由胱硫醚-γ-裂解酶催化合成,参与心血管生理功能的调控和病理生理过程,具有舒张血管、降低血压、抑制血管平滑肌细胞增生、抗氧化等多种生物学效应,与高血压、高血脂、动脉粥样硬化、冠心病等多种心血管疾病相关,本文将对内源性硫化氢的生化、生理特性,在心血管疾病中的病理生理作用等有关问题进行概述.
내원성류화경시제3개피발현적기체신사분자.재심혈관계통,류화경주요유광류미-γ-렬해매최화합성,삼여심혈관생리공능적조공화병리생리과정,구유서장혈관、강저혈압、억제혈관평활기세포증생、항양화등다충생물학효응,여고혈압、고혈지、동맥죽양경화、관심병등다충심혈관질병상관,본문장대내원성류화경적생화、생리특성,재심혈관질병중적병리생리작용등유관문제진행개술.
Endogenous hydrogen sulfide (H_2S) is to third found gaseous transmitter.In cardiovascular system, H_2S is produced endogenously by cystathionine γ-lyase (CSE)and plays an important role in the regulation of cardiovascular physiologic function and patho physiological processes.The CSE/H_2S system has a variety of biological effects in the cardiovascular system, such as inducing vasorelaxation,decreases blood pressure,inhibiting vascular smooth muscle cell proliferation and inducing anti-oxidant.It is also concerned with variety of cardiovascular diseases such as hypertension, hyperlipemia, atherosclerosis,coronary artery disease and so on.We summarize the biochemical characteristics and the physiological functions of endogenous H_2S and its patho physiological effects in cardiovascular diseases.