CAJ | 학술논문

目的探讨乳腺浸润性导管癌(IDC)患者雌激素受体(ER)、孕激素受体(PR)、人类上皮生长因子受体(HER-2)表达水平与灰阶超声特征的相关性.方法对术前应用超声检查的73例IDC患者的灰阶超声图像特征与术后标本经免疫组织化学染色检测ER、PR、HER一2表达情况进行对比研究.结果肿瘤有毛刺(蟹足)征、周边高回声晕、肿瘤后方衰减组ER阳性表达率高于肿瘤无毛刺(蟹足)征、无周边高回声晕、肿瘤后方无衰减组,差异有统计学意义(P＜0.01);肿瘤内微钙化、腋窝肿大淋巴结组HER-2表达阳性率高于肿瘤内无微钙化、腋窝无肿大淋巴结组,差异有统计学意义(P＜0.05).结论 ER、HER-2表达与IDC灰阶超声特征之间存在相关性,灰阶超声征象可对部分乳腺浸润性导管癌的预后及生物学特性作出初步判断.
목적 탐토유선침윤성도관암(IDC)환자자격소수체(ER)、잉격소수체(PR)、인류상피생장인자수체(HER-2)표체수평여회계초성특정적상관성.방법 대술전응용초성검사적73례IDC환자적회계초성도상특정여술후표본경면역조직화학염색검측ER、PR、HER일2표체정황진행대비연구.결과 종류유모자(해족)정、주변고회성훈、종류후방쇠감조ER양성표체솔고우종류무모자(해족)정、무주변고회성훈、종류후방무쇠감조,차이유통계학의의(P＜0.01);종류내미개화、액와종대림파결조HER-2표체양성솔고우종류내무미개화、액와무종대림파결조,차이유통계학의의(P＜0.05).결론 ER、HER-2표체여IDC회계초성특정지간존재상관성,회계초성정상가대부분유선침윤성도관암적예후급생물학특성작출초보판단.
Objective To evaluate the relationship between the grey scale ultrasonographic feature and estrogen receptor(ER),progesterone receptor(PR)or human epidermal growth factor receptor-2(HER-2)expression in infiltrating ductal cancer(IDC)of breast.Methods Seventy-three patients with IDC confirmed pathologically were involved in this study.The specimens wete examined immunohistochemistically to judge the expression of the related factors.ER,PR and HER-2 expression of the mastectomy specimens were determined with immunohistochemical staining technique.The correlation between the ultrasonographic features and ER,PR or HER-2 positive expression was analyzed. Results The ER positive rate in lesions with the spicule sign,echogenic halo or posterior shadowing were higher than in lesions without the spicule sign,echogenic halo or posterior shadowing(P＜0.01).The HER-2 positive rate in lesion with the calcifications and lymphadenectasis in axillary was higher than that in lesions without calcifications,or lymphadenectasis in axillary(P＜0.05).Conclusions A certain correlation exists between the ultrasonographic features and ER,HER-2 expression in patients with IDC.