CAJ | 학술논문

目的应用实时超声造影技术结合时间-强度曲线定量评价不同程度肝硬化患者肾血流灌注情况.方法常规肾功能正常的肝硬化患者40例,据肝功能Child-Pugh分级法分为Child-PughA级组14例,B级组14例,C级组12例.以30例正常人为对照,比较不同程度肝硬化患者肾血流灌注及时间-强度曲线量化参数,并与Child-Pugh评分进行关联性分析.结果与正常组比较,肝硬化组肾皮质血流灌注峰值强度减低,达峰时间延长,曲线下面积减小(P＜0.05)；与A级组比较,B级组峰值强度减低,C级组峰值强度减低、达峰时间延长(P ＜0.05或P＜0.01).峰值强度与肝硬化组Child-Pugb评分呈负相关(r=-0.506,P＜0.01).结论超声造影结合时间-强度曲线可定量评估不同程度肝硬化患者肾血流灌注,峰值强度与肝硬化的病变程度密切相关.
목적 응용실시초성조영기술결합시간-강도곡선정량평개불동정도간경화환자신혈류관주정황.방법 상규신공능정상적간경화환자40례,거간공능Child-Pugh분급법분위Child-PughA급조14례,B급조14례,C급조12례.이30례정상인위대조,비교불동정도간경화환자신혈류관주급시간-강도곡선양화삼수,병여Child-Pugh평분진행관련성분석.결과 여정상조비교,간경화조신피질혈류관주봉치강도감저,체봉시간연장,곡선하면적감소(P＜0.05)；여A급조비교,B급조봉치강도감저,C급조봉치강도감저、체봉시간연장(P ＜0.05혹P＜0.01).봉치강도여간경화조Child-Pugb평분정부상관(r=-0.506,P＜0.01).결론 초성조영결합시간-강도곡선가정량평고불동정도간경화환자신혈류관주,봉치강도여간경화적병변정도밀절상관.
Objective To assess the renal perfusion of different severity of hepatic cirrhosis by contrast-enhanced ultrasound with time-intensity curve.Methods Forty hepatic cirrhosis patients with normal conventional renal function enrolled the study and were subdivided into Child-Pugh A group ( n =14),Child-Pugh B group ( n =14) and Child-Pugh C group ( n =12).Thirty healthy subjects were selected as the control group.The parameters of perfusion were compared among the groups.The correlations between parameters and score of Child-Pugh were analyzed using Pearson correlation.Results The cirrhosis groups showed a decrease of peak intensity,increase of time to peak,and reduce of area under the curve in the renal cortex( P ＜0.05).Compared with Child-Pugh A group,the peak intensity decreased in both ChildPugh B and C groups,time to peak increased in Child-Pugh C group( P ＜0.05 or P ＜0.01 ).The peak intensity had negative correlation with Child-Pugh score( r =- 0.506,P ＜0.01 ).Conclusions Contrastenhanced ultrasound combined with time-intensity curve can assess renal perfusion of hepatic cirrhosis quantitatively.The peak intensity was correlated to the severity of cirrhosis.