中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2011年
12期
881-883
,共3页
杨春霞%杨微波%范晶华%陈一晖%张艳梅%周菊%迟晓伟%徐丽
楊春霞%楊微波%範晶華%陳一暉%張豔梅%週菊%遲曉偉%徐麗
양춘하%양미파%범정화%진일휘%장염매%주국%지효위%서려
肝炎,乙型,慢性%年龄分布%病理学,临床%活组织检查,肝
肝炎,乙型,慢性%年齡分佈%病理學,臨床%活組織檢查,肝
간염,을형,만성%년령분포%병이학,림상%활조직검사,간
Hepatitis B,chronic%Age distribution%Pathology,clinical%Biopsy,liver
目的 分析各年龄段慢性HBV携带者肝活组织检查病理炎症分级≥G2级或纤维化分期≥S2者所占比例,探讨肝活组织检查最佳时机,指导抗病毒治疗. 方法 收集292例慢性HBV携带者肝活组织检查病理结果,按年龄分为3组,计算各年龄段炎症分级≥G2或纤维化分期≥S2者各占比例,比较组间差异.计数资料统计学描述用构成比,统计分析采用x2检验.P＜ 0.01为差异具有统计学意义. 结果 3个年龄段慢性HBV携带者炎症分级≥G2级或纤维化分期≥S2者,在11 ～ 29岁组占26.5％ (36/136),30～39岁组占39.4％ (37/94),40～60岁组占58.1％ (36/62),总体差异有统计学意义(P＜ 0.01).30 ～ 39岁组炎症分级≥G2级或纤维化分期≥S2者的比例为39.4％ (37/94),与40～60岁组58.1％ (36/62)比较,差异无统计学意义(P＞0.01).且30岁以前的慢性HBV携带者炎症分级≥G2级或纤维化分期≥S2者占26.5％(36/136),30岁以后的慢性HBV携带者炎症分级≥G2级或纤维化分期≥S2者占46.8％(73/156),差异有统计学意义(P＜0.01). 结论 年龄≥30岁为慢性HBV携带者肝活组织检查最佳时机,因此,对≥30岁慢性HBV携带者应尽早做肝穿刺活组织检查,对预防疾病发展,指导抗病毒治疗有重要意义.
目的 分析各年齡段慢性HBV攜帶者肝活組織檢查病理炎癥分級≥G2級或纖維化分期≥S2者所佔比例,探討肝活組織檢查最佳時機,指導抗病毒治療. 方法 收集292例慢性HBV攜帶者肝活組織檢查病理結果,按年齡分為3組,計算各年齡段炎癥分級≥G2或纖維化分期≥S2者各佔比例,比較組間差異.計數資料統計學描述用構成比,統計分析採用x2檢驗.P＜ 0.01為差異具有統計學意義. 結果 3箇年齡段慢性HBV攜帶者炎癥分級≥G2級或纖維化分期≥S2者,在11 ～ 29歲組佔26.5％ (36/136),30～39歲組佔39.4％ (37/94),40～60歲組佔58.1％ (36/62),總體差異有統計學意義(P＜ 0.01).30 ～ 39歲組炎癥分級≥G2級或纖維化分期≥S2者的比例為39.4％ (37/94),與40～60歲組58.1％ (36/62)比較,差異無統計學意義(P＞0.01).且30歲以前的慢性HBV攜帶者炎癥分級≥G2級或纖維化分期≥S2者佔26.5％(36/136),30歲以後的慢性HBV攜帶者炎癥分級≥G2級或纖維化分期≥S2者佔46.8％(73/156),差異有統計學意義(P＜0.01). 結論 年齡≥30歲為慢性HBV攜帶者肝活組織檢查最佳時機,因此,對≥30歲慢性HBV攜帶者應儘早做肝穿刺活組織檢查,對預防疾病髮展,指導抗病毒治療有重要意義.
목적 분석각년령단만성HBV휴대자간활조직검사병리염증분급≥G2급혹섬유화분기≥S2자소점비례,탐토간활조직검사최가시궤,지도항병독치료. 방법 수집292례만성HBV휴대자간활조직검사병리결과,안년령분위3조,계산각년령단염증분급≥G2혹섬유화분기≥S2자각점비례,비교조간차이.계수자료통계학묘술용구성비,통계분석채용x2검험.P＜ 0.01위차이구유통계학의의. 결과 3개년령단만성HBV휴대자염증분급≥G2급혹섬유화분기≥S2자,재11 ～ 29세조점26.5％ (36/136),30～39세조점39.4％ (37/94),40～60세조점58.1％ (36/62),총체차이유통계학의의(P＜ 0.01).30 ～ 39세조염증분급≥G2급혹섬유화분기≥S2자적비례위39.4％ (37/94),여40～60세조58.1％ (36/62)비교,차이무통계학의의(P＞0.01).차30세이전적만성HBV휴대자염증분급≥G2급혹섬유화분기≥S2자점26.5％(36/136),30세이후적만성HBV휴대자염증분급≥G2급혹섬유화분기≥S2자점46.8％(73/156),차이유통계학의의(P＜0.01). 결론 년령≥30세위만성HBV휴대자간활조직검사최가시궤,인차,대≥30세만성HBV휴대자응진조주간천자활조직검사,대예방질병발전,지도항병독치료유중요의의.
Objective To study the best time of taking liver biopsy for chronic HBV carriers of age ranges and then guiding antiretroviral treatment.Method The liver biopsy pathologic results of 292 cases of chronic HBV carriers were collected from the First Affiliated Hospital of Kunming Medical College.The patients were divided into three groups according to ages.The differences between groups were compared by calculating the ratio of inflammation above G2 or fibrosis staging above S2.Result The percentages of the chronic HBV carriers with liver histopathology irflamination graded above G2 or fibrosis staging above S2 were 26.5％ (36/136) in 11-29 year-old group,39.4％ (37/94) in 30-39 year-old group and 58.1％ (36/62) in 40-60 year-old group.Significant difference existed among groups in general ( P ＜ 0.01).39.4％ (37/94) of chronic HBV carriers were found with inflammation graded above G2 or fibrosis staging above S2 in 30-39 year-old group,no statistically significant defference found between group 30-39 years old and group and 40- 60 years old 58.1％ (36/62) (P＜ 0.01).26.5％ (36/136) of chronic HBV carriers under 30 years old were with inflammation graded above G2 or fibrosis staging above S2 as compared with the percentage of 46.8％ (73/156) in the chronic HBV carriers over 30 years old group,and significant defference existed between the two groups ( P ＜ 0.01).Conclusion The best time choice of taking liver biopsy should be at the ages elder than or equal to 30.
