CAJ | 학술논문

目的评价复合海绵及其载药后对兔肝、脾创面的局部止血性能.方法采用复合交联、冷冻干燥得到复合海绵;将其浸入一定浓度的氨甲环酸中,冻干得载药复合海绵.在兔肝、脾损伤创面,分别敷用复合海绵和载药复合海绵,观察正常情况下和肝素抗凝后兔肝、脾创面的出血时间及出血量,并与可吸收性明胶海绵和壳聚糖海绵比较.结果正常情况下,复合海绵的止血时间和出血量较明胶海绵组和壳聚糖海绵组缩短或减少(P＜0.05,0.01);在肝素抗凝后,明胶海绵止血时间明显延长,而壳聚糖海绵和复合海绵的变化并不明显.载药复合海绵与复合海绵相比,在正常状态下止血性能有明显提高,但在凝血功能障碍时止血性能没有显著变化,且止血性能与载药量不呈线性关系.结论复合海绵和载氨甲环酸复合海绵较明胶海绵止血性能明显提高,尤其是在凝血功能障碍时.
목적 평개복합해면급기재약후대토간、비창면적국부지혈성능.방법 채용복합교련、냉동간조득도복합해면;장기침입일정농도적안갑배산중,동간득재약복합해면.재토간、비손상창면,분별부용복합해면화재약복합해면,관찰정상정황하화간소항응후토간、비창면적출혈시간급출혈량,병여가흡수성명효해면화각취당해면비교.결과 정상정황하,복합해면적지혈시간화출혈량교명효해면조화각취당해면조축단혹감소(P＜0.05,0.01);재간소항응후,명효해면지혈시간명현연장,이각취당해면화복합해면적변화병불명현.재약복합해면여복합해면상비,재정상상태하지혈성능유명현제고,단재응혈공능장애시지혈성능몰유현저변화,차지혈성능여재약량불정선성관계.결론 복합해면화재안갑배산복합해면교명효해면지혈성능명현제고,우기시재응혈공능장애시.
Objective To evaluate the hemostatic efficacy of complex sponge and drug-loaded complex sponge on hepatic and splenic wounds in rabbits. Methods Complex sponge was prepared by means of cross-linking and lyophilization. Then, the sponge was immersed into the tranexamic acid solution and lyophilized to obtain the drug-loaded sponge. The complex sponge and drug-loaded complex sponge were respectively used on the hepatic and splenic wounds of rabbits to observe the bleeding time and blood loss under normal and liquemine anticoagulation respectively. The gelatin sponge and the chitosan sponge were used as controls. Results Under normal condition, the hemostatic time and blood loss of the complex sponge was decreased obviously compared with the gelatin sponge ( P＜ 0. 01 ) and compared with the chitosan sponge ( P ＜ 0. 05 ). Posterior to liquemine anticoagulation, the hemostatic time was increased obviously in the gelatin sponge but showed no difference for the chitosan sponge and the complex sponge. Compared with complex sponge, the hemostatic efficacy of the tranexamic acid-loaded complex sponge was improved markedly for normal rabbits. While the hemostatic efficacy showed no significant change for rabbits with coagulation disorders, when there was no linear relationship between the hemostatic efficacy and the content of tranexamic acid. Conclusions The hemostatic efficacy of the complex sponge and the drug-loaded complex sponge surpass obviously that of the gelatin sponge, especially for the rabbits with coagulation disorders.