CAJ | 학술논문

60只SD大鼠分别给予正常饲料和高脂饲料喂养,8周后高脂组中选取肥胖大鼠给予腹腔内注射小剂量链脲佐菌素制备糖尿病模型.成模大鼠分为安慰剂、二氮嗪和格列吡嗪组,治疗4周.结果显示,2型糖尿病模型肥胖大鼠体重、胰岛素、胰岛素敏感性显著低于高脂对照组(P＜0.01).与格列吡嗪相似,二氮嗪可降低血糖,改善葡萄糖耐量(P＜0.01),2组之间无显著差异(P＞0.05).二氮嗪组胰岛的形态基本完整,胰岛细胞凋亡率显著低于糖尿病组(P＜0.05),同格列吡嗪组相比无显著差异(P＞0.05).提示二氮嗪作为KATP通道开放剂,能促进胰岛细胞休息,减轻胰岛素分泌负荷,改善2型糖尿病肥胖大鼠的胰岛功能.
60지SD대서분별급여정상사료화고지사료위양,8주후고지조중선취비반대서급여복강내주사소제량련뇨좌균소제비당뇨병모형.성모대서분위안위제、이담진화격렬필진조,치료4주.결과현시,2형당뇨병모형비반대서체중、이도소、이도소민감성현저저우고지대조조(P＜0.01).여격렬필진상사,이담진가강저혈당,개선포도당내량(P＜0.01),2조지간무현저차이(P＞0.05).이담진조이도적형태기본완정,이도세포조망솔현저저우당뇨병조(P＜0.05),동격렬필진조상비무현저차이(P＞0.05).제시이담진작위KATP통도개방제,능촉진이도세포휴식,감경이도소분비부하,개선2형당뇨병비반대서적이도공능.
Sixty male SD rats were separately fed by normal diet or high-fat diet.After eight weeks of highfat diet,these rats were injected low dose streptozotocin (30 mg/kg).Diazoxide or glipizide was administered to the diabetic rats for 4 weeks.The results showed that body weight,serum insulin,and insulin sensitive index were decreased in the obese diabetic rats while the fasting blood glucose,total cholesterol,and triglyceride levels were increased compared with the high-fat diet group ( all P＜0.01 ).Consistent with the results of glipizide,diazoxide treatment lowered blood glucose,improved glucose tolerance,and decreased islet cell apoptosis compared with the diabetes mellitus group ( all P＜0.05 ).The results suggest that diazoxide can improve islet function of obese type 2 diabetic rats via decreasing insulin secretion and thus lessening the load on islet cells.