CAJ | 학술논문

目的应用彩色超声多普勒探讨社区相对健康中老年人群颈动脉内-中膜厚度(CCA-IMT)和斑块(CP)形成、分布、数目与性质. 方法 1930例相对健康中老年人从《广州生物库队列研究》随机选取,应用彩色多普勒超声仪检测颈动脉各项指标.比较性别、年龄对颈动脉硬化的影响.结果男性CCA-IMT和CP发生率分别为41.5％ (400/963)和34.1％ (328/967),明显高于女性16.2％(157/967)和13.8％(133/967)(均P＜0.001).按年龄分为50～59岁、60～69岁和70～79岁3组,无论是男性或女性,左或右侧CCA-IMT均呈现随年龄增加而明显增厚(均P＜0.001).颈动脉斑块形成的种类以溃疡斑(37.8％)最多见,其次分别为硬斑(24.9％)、软斑(22.1％)和扁平斑(15.2％),斑块好发部位依次是颈动脉的交叉处(61.7％)、颈总动脉(21.0％)和颈内动脉(17.3％)；50～59岁年龄组的斑块发生率女性为44.4％ (83/87),明显高于男性的20.9％(108/517),而年龄在60岁或以上者则男性为79.1％(409/571),明显高于女性的55.6％ (104/187). 结论年龄在60岁或以上者男性颈动脉斑块发生率高,溃疡斑最多见,斑块好发部位是颈动脉的交叉处.
목적 응용채색초성다보륵탐토사구상대건강중노년인군경동맥내-중막후도(CCA-IMT)화반괴(CP)형성、분포、수목여성질. 방법 1930례상대건강중노년인종《엄주생물고대렬연구》수궤선취,응용채색다보륵초성의검측경동맥각항지표.비교성별、년령대경동맥경화적영향.결과 남성CCA-IMT화CP발생솔분별위41.5％ (400/963)화34.1％ (328/967),명현고우녀성16.2％(157/967)화13.8％(133/967)(균P＜0.001).안년령분위50～59세、60～69세화70～79세3조,무론시남성혹녀성,좌혹우측CCA-IMT균정현수년령증가이명현증후(균P＜0.001).경동맥반괴형성적충류이궤양반(37.8％)최다견,기차분별위경반(24.9％)、연반(22.1％)화편평반(15.2％),반괴호발부위의차시경동맥적교차처(61.7％)、경총동맥(21.0％)화경내동맥(17.3％)；50～59세년령조적반괴발생솔녀성위44.4％ (83/87),명현고우남성적20.9％(108/517),이년령재60세혹이상자칙남성위79.1％(409/571),명현고우녀성적55.6％ (104/187). 결론 년령재60세혹이상자남성경동맥반괴발생솔고,궤양반최다견,반괴호발부위시경동맥적교차처.
Objective To investigate the prevalence and charateristics of carotid atherosclerosis among healthy middle-aged people of community. Methods Totally 1930 subjects aged 50 years and above were selected randomly from 10027 participants recruited during Phase 3 of the Guangzhou Biobank Cohort Study (GBCS).Common carotid artery intima-media thickness (CCA-IMT) and carotid plaques (CP) were measured by B-mode ultrasonography using ALT HDI 3000 mainframe with a high-resolution. Results The prevalences of CCA-IMT and CP in men were higher than women [41.5％(400/963)vs.16.2 (157/967),34.1％ (328/967) vs.13.8％ (133/967),both P＜0.001].The prevalence of CCA-1MT was higher with age increasing in either men or women in groups of 50-yrs,60-yrs and 70-79 yrs (all P＜0.001).The most of CP was cankerous spot (37.8％),secondly hard spot (24.9％),soft spot (22.1％) and the prevalence of flat spot was lowest (15.2％).The number of CP was not significantly different between the left and right side (51.0％ and 49.0％).The most common location of CP was bifurcations of carotid arteries (61.7 ％),next the common carotid artery (21.0％) and internal carotid artery (ICA) was lowest (17.3 ％).The prevalence of CP was 44.4％ (83/87) in women aged 50- yrs,it was higher than that in men 20.9％ (108/517).However,the prevalence of CP was 79.1％ (409/517) in men aged more than 60 yrs,higher than that in women (55.6％). Conclusions The carotid atherosclerosis is commonly encountered disease in the male elderly,and the most of CP was cankerous spot in bifurcations of carotid arteries