中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2012年
4期
459-463
,共5页
王佳%马小红%向波%吴俊瑶%王英成%邓伟%李名立%王强%何宗岭%李涛
王佳%馬小紅%嚮波%吳俊瑤%王英成%鄧偉%李名立%王彊%何宗嶺%李濤
왕가%마소홍%향파%오준요%왕영성%산위%리명립%왕강%하종령%리도
精神分裂症%一氧化氮合酶1基因%单核苷酸多态性%关联分析
精神分裂癥%一氧化氮閤酶1基因%單覈苷痠多態性%關聯分析
정신분렬증%일양화담합매1기인%단핵감산다태성%관련분석
Schizophrenia%Nitric oxide synthase 1%Single nucleotide polymorphisms%Association study
目的 探讨一氧化氮合酶1(nitric oxide synthase 1,NOS1)基因多态性与精神分裂症易感性的相关性.方法 选取NOS1区域的28个标签单核苷酸多态性(single nucleotide polymorphisms,SNPs)位点,应用Illumina GoldenGate定制芯片对382例汉族精神分裂症患者和448名正常人的DNA进行分型,并分析其与精神分裂症的相关性.结果 单位点分析提示SNP位点rs1520811与精神分裂症存在关联,但是经过Bonferroni多重校正后差异无统计学意义(P＞0.05).单体型分析未发现单体型与精神分裂症的相关性.结论 未证实NOS1为精神分裂症的易感基因.
目的 探討一氧化氮閤酶1(nitric oxide synthase 1,NOS1)基因多態性與精神分裂癥易感性的相關性.方法 選取NOS1區域的28箇標籤單覈苷痠多態性(single nucleotide polymorphisms,SNPs)位點,應用Illumina GoldenGate定製芯片對382例漢族精神分裂癥患者和448名正常人的DNA進行分型,併分析其與精神分裂癥的相關性.結果 單位點分析提示SNP位點rs1520811與精神分裂癥存在關聯,但是經過Bonferroni多重校正後差異無統計學意義(P＞0.05).單體型分析未髮現單體型與精神分裂癥的相關性.結論 未證實NOS1為精神分裂癥的易感基因.
목적 탐토일양화담합매1(nitric oxide synthase 1,NOS1)기인다태성여정신분렬증역감성적상관성.방법 선취NOS1구역적28개표첨단핵감산다태성(single nucleotide polymorphisms,SNPs)위점,응용Illumina GoldenGate정제심편대382례한족정신분렬증환자화448명정상인적DNA진행분형,병분석기여정신분렬증적상관성.결과 단위점분석제시SNP위점rs1520811여정신분렬증존재관련,단시경과Bonferroni다중교정후차이무통계학의의(P＞0.05).단체형분석미발현단체형여정신분렬증적상관성.결론 미증실NOS1위정신분렬증적역감기인.
Objective To assess the association between nitric oxide synthase 1 (NOS1)gene polymorphisms and schizophrenia.Methods Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.Results One SNP (rs1520811) was found to be associated with schizophrenia,which however becomes negative after Bonferroni correction (P＞ 0.05).Further analysis has failed to identify any association between particular haplotypes and the disease.Conclusion Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
