CAJ | 학술논문

目的观察窄谱中波紫外线(NB-UVB)预照射对稳定期白癜风自体表皮移植疗效的影响.方法将82例稳定期白癜风患者随机分为治疗组与对照组,治疗组患者13斑处首先进行8次以上NB-UVB照射,然后行自体表皮移植治疗;对照组单纯行自体表皮移植治疗.跟踪随访3个月观察疗效.结果 NB-UVB照射可明显提高自体表皮移植患者皮片的存活和复色率,疗效明显优于对照组(P＜0.05);治疗组散在性白癜风的痊愈率明显高于对照组(P＜0.05);疗效与照射次数、移植部位、色素出现时间等有关.结论 NB-UVB预照射可明显提高稳定期白癜风自体表皮移植的疗效.
목적 관찰착보중파자외선(NB-UVB)예조사대은정기백전풍자체표피이식료효적영향.방법 장82례은정기백전풍환자수궤분위치료조여대조조,치료조환자13반처수선진행8차이상NB-UVB조사,연후행자체표피이식치료;대조조단순행자체표피이식치료.근종수방3개월관찰료효.결과 NB-UVB조사가명현제고자체표피이식환자피편적존활화복색솔,료효명현우우대조조(P＜0.05);치료조산재성백전풍적전유솔명현고우대조조(P＜0.05);료효여조사차수、이식부위、색소출현시간등유관.결론 NB-UVB예조사가명현제고은정기백전풍자체표피이식적료효.
Objective To observe the curative effect of narrow-band ultraviolet(NB-UVB)on stable vitiligo with autologous epidermis grafting.Methods A total of 82 patients with stable vitiligo were recruited and randomly divided into a control group and a treatment group.The patients in the treatment group were pretreated with NB-UVB before autologous epidermis grafting,while those in the control group were not.The pretreatment with NB-UVB was implemented twice a week for at least 4 weeks before the autologous epidermis grafting. A 3-month follow-up observation was conducted with regard to the effectiveness. Results Pretreatment with NB-UVB could significantly increase the survival rate of skin grafts and rate of repigment of leukoplakia,when compared with autologous epidermises transplantation alone.The rate of complete repigment raised significantly(P＜0.05),and so did the curative effect for vulgaris generalized vitiligo(P＜0.029).It was found that the curative effect on vitiligo was closely related to the frequency of NB-UVB radiation,location of leukoplakia,color of skin,and the time of repigment appearance. ConclusiOn Pretreatment with NB-UVB can significantly improve curative effect of autologous epidermis grafting on vitiligo.