CAJ | 학술논문

目的探讨血清中高尔基体蛋白73( GP73)、甲胎蛋白(AFP)和甲胎蛋白异质体(AFP-L3)单独和联合检测对原发性肝癌(PHC)诊断的意义，为PHC诊断和普查提供一种新方法。方法采用ELISA对81例PHC、176例慢性肝炎和肝硬化、30例其他肿瘤疾病和40名健康人的血清GP73、甲胎蛋白异质体( AFP-L3)和AFP进行检测。结果 GP73、AFP和AFP-L3在肝癌组的敏感度分别为77.78％、62.69％和51.85％，在非肝癌组的特异性分别为84.55％、86.99％和96.34％。三者联合检测时，其诊断的敏感度可提高至88.89％。结论 GP73对PHC诊断具有较好的敏感度，AFP-L3具有较高的特异性。血清GP73、AFP和AFP-L3联合检测可有效提高PHC的临床诊断效果。
목적 탐토혈청중고이기체단백73( GP73)、갑태단백(AFP)화갑태단백이질체(AFP-L3)단독화연합검측대원발성간암(PHC)진단적의의，위PHC진단화보사제공일충신방법。방법채용ELISA대81례PHC、176례만성간염화간경화、30례기타종류질병화40명건강인적혈청GP73、갑태단백이질체( AFP-L3)화AFP진행검측。결과 GP73、AFP화AFP-L3재간암조적민감도분별위77.78％、62.69％화51.85％，재비간암조적특이성분별위84.55％、86.99％화96.34％。삼자연합검측시，기진단적민감도가제고지88.89％。결론 GP73대PHC진단구유교호적민감도，AFP-L3구유교고적특이성。혈청GP73、AFP화AFP-L3연합검측가유효제고PHC적림상진단효과。
Objective To explore the alone and joint diagnostic value of serum golgi protein 73 (GP73), alpha-fetoprotein ( AFP) and the percentage of lectin-reactive alpha-fetoprotein ( AFP-L3 ) of primary hepatic carcinoma (PHC) ,and provide a novel method for diagnosis for PHC and screening for highrisk population. Methods ELISA was used to detect the serum level of GP73, AFP and AFP-L3％ in 81 cases of PHC, 176 cases chronic hepatitis and liver cirrhosis , 30 cases other tumber cancer and 40 cases of health people. Results The sensitivity of GP73, AFP and AFP-L3％ in PHC is 77.78％ ,62.69％ and 51.85％ ,and the specificity is 84. 55％ ,86. 99％ and 96. 34％ ,respectively. Joint detection could increase the sensitivity up to 88.89％. Conclusion GP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3％ was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.