国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2010年
4期
37-40
,共4页
顾谊铮%岑俊%魏莉莉%伏春明%王雪英%王传祥%余杰
顧誼錚%岑俊%魏莉莉%伏春明%王雪英%王傳祥%餘傑
고의쟁%잠준%위리리%복춘명%왕설영%왕전상%여걸
血液透析%脂联素%瘦素%抵抗素
血液透析%脂聯素%瘦素%牴抗素
혈액투석%지련소%수소%저항소
Hemodialysis%Adiponectin%Leptin%Resistin
目的 探讨维持性血液透析患者血清脂肪细胞因子脂联素、瘦素、抵抗素的水平、相关影响因素及相互关系.方法 维持性血液透析患者79例,正常对照组16名.测定2组患者血清脂联素、瘦素、抵抗素、白蛋白、血脂等.分析脂联素、瘦素、抵抗素与这些参数的相关性.结果 维持性血液透析患者甘油三酯、脂联素、瘦素、抵抗素分别为(1.9±0.9)mmol/L、(14±9)mg/L、(105±109)g/L、(0.89±0.33)ng/ml,对照组分别为(1.4±0.5)mnloL/L、(6±4)mg/L、(52±19)异/L、(0.44±0.20)ng//ml,两组比较差异有统计学意义(P<0.05、0.01),而白蛋白(38±4)g/L、高密度脂蛋白(1.3±0.3)mmol/L与对照组[(43±6)g/L、(1.5±0.3)mmol/L]比较差异有统计学意义(P<0.05),维持性血液透析患者胆同醇(4.1±0.9)mmol/L、低密度脂蛋白(2.3±0.7)mmol/L与对照组((4.2±0.9)mmoL/L、(2.1±1.0)mmol/L]比较差异无统计学意义(P>0.05).多元逐步回归分析结果显示,体重指数、高密度脂蛋白、腰臀围比是血清脂联素的独立影响因素.性别和体重指数是血清瘦素的独立影响因素.血清抵抗素与各项临床资料、生化指标的相关性均无显著性.血清脂联素与瘦素呈显著负相关(r:0.232,P<0.01).结论 维持性血液透析患者脂联素、瘦素和抵抗素的水平可能是营养、脂代谢及心血管疾病之间的联系因子.
目的 探討維持性血液透析患者血清脂肪細胞因子脂聯素、瘦素、牴抗素的水平、相關影響因素及相互關繫.方法 維持性血液透析患者79例,正常對照組16名.測定2組患者血清脂聯素、瘦素、牴抗素、白蛋白、血脂等.分析脂聯素、瘦素、牴抗素與這些參數的相關性.結果 維持性血液透析患者甘油三酯、脂聯素、瘦素、牴抗素分彆為(1.9±0.9)mmol/L、(14±9)mg/L、(105±109)g/L、(0.89±0.33)ng/ml,對照組分彆為(1.4±0.5)mnloL/L、(6±4)mg/L、(52±19)異/L、(0.44±0.20)ng//ml,兩組比較差異有統計學意義(P<0.05、0.01),而白蛋白(38±4)g/L、高密度脂蛋白(1.3±0.3)mmol/L與對照組[(43±6)g/L、(1.5±0.3)mmol/L]比較差異有統計學意義(P<0.05),維持性血液透析患者膽同醇(4.1±0.9)mmol/L、低密度脂蛋白(2.3±0.7)mmol/L與對照組((4.2±0.9)mmoL/L、(2.1±1.0)mmol/L]比較差異無統計學意義(P>0.05).多元逐步迴歸分析結果顯示,體重指數、高密度脂蛋白、腰臀圍比是血清脂聯素的獨立影響因素.性彆和體重指數是血清瘦素的獨立影響因素.血清牴抗素與各項臨床資料、生化指標的相關性均無顯著性.血清脂聯素與瘦素呈顯著負相關(r:0.232,P<0.01).結論 維持性血液透析患者脂聯素、瘦素和牴抗素的水平可能是營養、脂代謝及心血管疾病之間的聯繫因子.
목적 탐토유지성혈액투석환자혈청지방세포인자지련소、수소、저항소적수평、상관영향인소급상호관계.방법 유지성혈액투석환자79례,정상대조조16명.측정2조환자혈청지련소、수소、저항소、백단백、혈지등.분석지련소、수소、저항소여저사삼수적상관성.결과 유지성혈액투석환자감유삼지、지련소、수소、저항소분별위(1.9±0.9)mmol/L、(14±9)mg/L、(105±109)g/L、(0.89±0.33)ng/ml,대조조분별위(1.4±0.5)mnloL/L、(6±4)mg/L、(52±19)이/L、(0.44±0.20)ng//ml,량조비교차이유통계학의의(P<0.05、0.01),이백단백(38±4)g/L、고밀도지단백(1.3±0.3)mmol/L여대조조[(43±6)g/L、(1.5±0.3)mmol/L]비교차이유통계학의의(P<0.05),유지성혈액투석환자담동순(4.1±0.9)mmol/L、저밀도지단백(2.3±0.7)mmol/L여대조조((4.2±0.9)mmoL/L、(2.1±1.0)mmol/L]비교차이무통계학의의(P>0.05).다원축보회귀분석결과현시,체중지수、고밀도지단백、요둔위비시혈청지련소적독립영향인소.성별화체중지수시혈청수소적독립영향인소.혈청저항소여각항림상자료、생화지표적상관성균무현저성.혈청지련소여수소정현저부상관(r:0.232,P<0.01).결론 유지성혈액투석환자지련소、수소화저항소적수평가능시영양、지대사급심혈관질병지간적련계인자.
Objective To characterize serum adiponectin( ADPN), leptin and resistin levels in pa tients undergoing maintenance hemodialysis (MHD), analyzed the correlation with ADPN, leptin,resistin and other factors.Methods We measured serum ADPN, leptin, resistin,albumin and lipide in 79 MHD patents and 16 healthy individuals. Results Serum TG, ADPN, leptin and,resistin levels of MHD patients were signif icantly higher than that of the healthy individuals [TG(1.9±0.9) mmol/L vs (1.4 ±0.5) mmol/L. ADPN (14±9) mg/Lvs(6±4) mg/L, leptin (105 ± 109)μg/L vs (52 ± 19)μg/L, resistin (0.89± 0.33) ng/ml vs (0.44 ± 0.20) ng/ml( P < 0.05) ]; however, albumin and HDL were significantly lower than that of the healthy individuals. Multiple regression analysis showed that BMI, HDL and WHR were the independent factors of ADPN.Gender ang BMI were the independent factors of leptin. Resistin had no correlation with all factors. ADPN was negative correlated with leptin.Conclusion The ADPN ,leptin and resistin level are significantly increased in MHD. ADPN and leptin may link with nutation ,liparoid metabolism and cardiovas cular diseases.
