CAJ | 학술논문

目的探讨CT灌注成像(CTPI)在老年性脑梗死脑血流动力学研究中的价值.方法 48例临床拟诊脑梗死的患者,发病24 h内行CT 16层平扫及CTPI检查,测定兴趣区的脑血流量(CBF)、对比剂平均通过时间(MTT)和对比剂峰值时间(TTP),并与对侧相应脑组织灌注参数比较;所有病例3～10 d后行MRI随访.结果本组中40.9%的患者CT平扫显示缺血灶,93.2%的患者CTPI显示异常灌注.CTPI发现异常灌注的敏感性为93.2%,特异性为100%;缺血区CBF减低,MTT、TTP延长,与对照区域比较差异有统计学意义(P＜0.01).结论 CTPI能够敏感地反映缺血脑组织的血流动力学状态,为老年性脑梗死的早期诊断、早期治疗提供重要信息.
목적 탐토CT관주성상(CTPI)재노년성뇌경사뇌혈류동역학연구중적개치.방법 48례림상의진뇌경사적환자,발병24 h내행CT 16층평소급CTPI검사,측정흥취구적뇌혈류량(CBF)、대비제평균통과시간(MTT)화대비제봉치시간(TTP),병여대측상응뇌조직관주삼수비교;소유병례3～10 d후행MRI수방.결과 본조중40.9%적환자CT평소현시결혈조,93.2%적환자CTPI현시이상관주.CTPI발현이상관주적민감성위93.2%,특이성위100%;결혈구CBF감저,MTT、TTP연장,여대조구역비교차이유통계학의의(P＜0.01).결론 CTPI능구민감지반영결혈뇌조직적혈류동역학상태,위노년성뇌경사적조기진단、조기치료제공중요신식.
Objective To study the value of CT perfusion imaging(CTPI)on brain hemodynamic of the aged with cerebral infarction. Methods The 48 patients who were doubted with cerebral infarction underwent 16-slice CT plain scanning and CTPI within 24 hours of onset. The cerebral blood flow(CBF), mean transit time(MTT)and time to peak(TTP)of contrast-medium in region of interest(FOV)were used as brain hemodynamic parameters in comparation with contralateral regions. All cases were followed up with MRI after 3-10 days. Results Ischemia lesion was found on CT plain scanning in 40.9% of patients, while 93.2% of patients showed abnormal perfusion on CTPI. The sensibility of CTPI in identifying ischemia area was 93.2%, and the specificity was 100%. CBF in research area was significantly reduced, MTT and TTP were remarkably increased in contrast to counterparts(P＜0.01). Conclusions CT perfusion imaging can sensitively reveal the hemodynamic condition of cerebral ischemia, which could provide the important information for early diagnosis and treatment of the elderly with brain infarction.